Literature DB >> 23461436

Detection of nitric oxide and nitroxyl with benzoresorufin-based fluorescent sensors.

Ulf-Peter Apfel1, Daniela Buccella, Justin J Wilson, Stephen J Lippard.   

Abstract

A new family of benzoresorufin-based copper complexes for fluorescence detection of NO and HNO is reported. The copper complexes, CuBRNO1-3, elicit 1.5-4.8-fold emission enhancement in response to NO and HNO. The three sensors differ in the nature of the metal-binding site. The photophysical properties of these sensors are investigated with assistance from density functional theory calculations. The fluorescence turn-on observed upon reaction with HNO is an unexpected result that is discussed in detail. The utility of the new sensors for detecting HNO and NO in HeLa cells and RAW 264.7 macrophages is demonstrated.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23461436     DOI： 10.1021/ic302793w

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  13 in total

1.  Copper (II)-doped semiconducting polymer dots for nitroxyl imaging in live cells.

Authors:  Xu Wu; Li Wu; I-Che Wu; Daniel T Chiu
Journal:  RSC Adv       Date:  2016-10-26       Impact factor: 3.361

Review 2.  Recent advances in the chemical biology of nitroxyl (HNO) detection and generation.

Authors:  Zhengrui Miao; S Bruce King
Journal:  Nitric Oxide       Date:  2016-04-20       Impact factor: 4.427

3.  The fluorescence regulation mechanism of the paramagnetic metal in a biological HNO sensor.

Authors:  Wenjing Yang; Xuebo Chen; Huizhen Su; Weihai Fang; Yong Zhang
Journal:  Chem Commun (Camb)       Date:  2015-06-14       Impact factor: 6.222

4.  Visualization of peroxynitrite-induced changes of labile Zn2+ in the endoplasmic reticulum with benzoresorufin-based fluorescent probes.

Authors:  Wei Lin; Daniela Buccella; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2013-09-03       Impact factor: 15.419

Review 5.  Specific Reactions of RSNO, HSNO, and HNO and Their Applications in the Design of Fluorescent Probes.

Authors:  Yingying Wang; Shi Xu; Ming Xian
Journal:  Chemistry       Date:  2020-07-20       Impact factor: 5.236

6.  A fast and selective near-infrared fluorescent sensor for multicolor imaging of biological nitroxyl (HNO).

Authors:  Alexandra T Wrobel; Timothy C Johnstone; Alexandria Deliz Liang; Stephen J Lippard; Pablo Rivera-Fuentes
Journal:  J Am Chem Soc       Date:  2014-03-13       Impact factor: 15.419

7.  Solid-phase synthesis provides a modular, lysine-based platform for fluorescent discrimination of nitroxyl and biological thiols.

Authors:  Andrei Loas; Robert J Radford; Alexandria Deliz Liang; Stephen J Lippard
Journal:  Chem Sci       Date:  2015-05-19       Impact factor: 9.825

8.  HNO to NO Conversion Mechanism with Copper Zinc Superoxide Dismutase, Comparison with Heme Protein Mediated Conversions, and the Origin of Questionable Reversibility.

Authors:  Yelu Shi; Matthew A Michael; Yong Zhang
Journal:  Chemistry       Date:  2021-02-16       Impact factor: 5.236

9.  HNO/NO Conversion Mechanisms of Cu-Based HNO Probes with Implications for Cu,Zn-SOD.

Authors:  Matthew A Michael; Gianna Pizzella; Liu Yang; Yelu Shi; Tiffany Evangelou; Daniel T Burke; Yong Zhang
Journal:  J Phys Chem Lett       Date:  2014-03-07       Impact factor: 6.475

10.  Addition of a second binding site increases the dynamic range but alters the cellular localization of a red fluorescent probe for mobile zinc.

Authors:  Andrei Loas; Robert J Radford; Stephen J Lippard
Journal:  Inorg Chem       Date:  2014-06-10       Impact factor: 5.165
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.