Literature DB >> 23457740

Telomeres, cancer & aging: live long & prosper?

Joel C Eissenberg1.   

Abstract

Like our clothes, our chromosomes fray at the edges with age. Some believe that if we could discover a molecular tailor to patch our age-abraded chromosome ends, we could become modern Methuselahs. Notably, cancer cells achieve immortality by protecting their chromosome ends. Drugs that selectively fray the ends of cancer cell chromosomes would be potent and general anti-cancer therapies. Here, I summarize data on the role of chromosome ends in cellular and organismal aging.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23457740      PMCID： PMC6179622     

Source DB:  PubMed          Journal:  Mo Med        ISSN： 0026-6620


  15 in total

1.  Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells.

Authors:  M A Shammas; C G Simmons; D R Corey; R J Shmookler Reis
Journal:  Oncogene       Date:  1999-11-04       Impact factor: 9.867

2.  Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination.

Authors:  Nuno M V Gomes; Oliver A Ryder; Marlys L Houck; Suellen J Charter; William Walker; Nicholas R Forsyth; Steven N Austad; Chris Venditti; Mark Pagel; Jerry W Shay; Woodring E Wright
Journal:  Aging Cell       Date:  2011-06-01       Impact factor: 9.304

Review 3.  Is telomere length a biomarker of aging? A review.

Authors:  Karen Anne Mather; Anthony Francis Jorm; Ruth Adeline Parslow; Helen Christensen
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-10-28       Impact factor: 6.053

4.  The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis.

Authors:  B McClintock
Journal:  Proc Natl Acad Sci U S A       Date:  1939-08       Impact factor: 11.205

5.  Extension of life-span by introduction of telomerase into normal human cells.

Authors:  A G Bodnar; M Ouellette; M Frolkis; S E Holt; C P Chiu; G B Morin; C B Harley; J W Shay; S Lichtsteiner; W E Wright
Journal:  Science       Date:  1998-01-16       Impact factor: 47.728

6.  Variability at the telomeres of the human X/Y pseudoautosomal region.

Authors:  H J Cooke; B A Smith
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1986

Review 7.  Telomeres and telomerase in cancer.

Authors:  Steven E Artandi; Ronald A DePinho
Journal:  Carcinogenesis       Date:  2009-11-03       Impact factor: 4.944

8.  Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

Authors:  E González-Suárez; E Samper; J M Flores; M A Blasco
Journal:  Nat Genet       Date:  2000-09       Impact factor: 38.330

9.  Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation.

Authors:  V J Cristofalo; R G Allen; R J Pignolo; B G Martin; J C Beck
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

10.  Telomere length predicts replicative capacity of human fibroblasts.

Authors:  R C Allsopp; H Vaziri; C Patterson; S Goldstein; E V Younglai; A B Futcher; C W Greider; C B Harley
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205
View more
  5 in total

1.  Beating the Odds on Lifespan.

Authors:  Joel C Eissenberg
Journal:  Mo Med       Date:  2018 Jul-Aug

2.  Copy neutral loss of heterozygosity is more frequent in older ovarian cancer patients.

Authors:  Brent S Pedersen; Panagiotis A Konstantinopoulos; Monique A Spillman; Subhajyoti De
Journal:  Genes Chromosomes Cancer       Date:  2013-05-28       Impact factor: 5.006

3.  Hungering for Immortality.

Authors:  Joel C Eissenberg
Journal:  Mo Med       Date:  2018 Jan-Feb

4.  Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence.

Authors:  Liwei Ma; Wenting Zhao; Feng Zhu; Fuwen Yuan; Nan Xie; Tingting Li; Pingzhang Wang; Tanjun Tong
Journal:  Front Endocrinol (Lausanne)       Date:  2015-05-15       Impact factor: 5.555

5.  MR molecular imaging of tumors based on an optimal hTERT promoter tyrosinase expression system.

Authors:  Chuan Li; Chang-Jiang Hu; Bo Tang; Xin Yong; Gang Luo; Yu-Yun Wu; Su-Min Wang; Song-Tao Yu; Shi-Ming Yang
Journal:  Oncotarget       Date:  2016-07-05
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.