Literature DB >> 21030466

Is telomere length a biomarker of aging? A review.

Karen Anne Mather1, Anthony Francis Jorm, Ruth Adeline Parslow, Helen Christensen.   

Abstract

Telomeres, the DNA-protein structures located at the ends of chromosomes, have been proposed to act as a biomarker of aging. In this review, the human evidence that telomere length is a biomarker of aging is evaluated. Although telomere length is implicated in cellular aging, the evidence suggesting telomere length is a biomarker of aging in humans is equivocal. More studies examining the relationships between telomere length and mortality and with measures that decline with "normal" aging in community samples are required. These studies would benefit from longitudinal measures of both telomere length and aging-related parameters.

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Year:  2010        PMID： 21030466     DOI： 10.1093/gerona/glq180

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  168 in total

1.  Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length.

Authors:  Priscila Tempaku; Camila Hirotsu; Diego Mazzotti; Gabriela Xavier; Pawan Maurya; Elisa Brietzke; Sintia Belangero; Dalva Poyares; Lia Bittencourt; Sergio Tufik
Journal:  J Clin Sleep Med       Date:  2018-12-15       Impact factor: 4.062

2.  Leukocyte telomere length is associated with noninvasively measured age-related disease: The Cardiovascular Health Study.

Authors:  Jason L Sanders; Annette L Fitzpatrick; Robert M Boudreau; Alice M Arnold; Abraham Aviv; Masayuki Kimura; Linda F Fried; Tamara B Harris; Anne B Newman
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-09-20       Impact factor: 6.053

3.  The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda.

Authors:  Terrie E Moffitt; Daniel W Belsky; Andrea Danese; Richie Poulton; Avshalom Caspi
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2016-10-07       Impact factor: 6.053

4.  Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia.

Authors:  Atsushi Narita; Hideki Muramatsu; Yuko Sekiya; Yusuke Okuno; Hirotoshi Sakaguchi; Nobuhiro Nishio; Nao Yoshida; Xinan Wang; Yinyan Xu; Nozomu Kawashima; Sayoko Doisaki; Asahito Hama; Yoshiyuki Takahashi; Kazuko Kudo; Hiroshi Moritake; Masao Kobayashi; Ryoji Kobayashi; Etsuro Ito; Hiromasa Yabe; Shouichi Ohga; Akira Ohara; Seiji Kojima
Journal:  Haematologica       Date:  2015-08-27       Impact factor: 9.941

5.  Select aging biomarkers based on telomere length and chronological age to build a biological age equation.

Authors:  Wei-Guang Zhang; Shu-Ying Zhu; Xiao-Juan Bai; De-Long Zhao; Shi-Min Jian; Juan Li; Zuo-Xiang Li; Bo Fu; Guang-Yan Cai; Xue-Feng Sun; Xiang-Mei Chen
Journal:  Age (Dordr)       Date:  2014-06

6.  Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood.

Authors:  Sonja Entringer; Elissa S Epel; Robert Kumsta; Jue Lin; Dirk H Hellhammer; Elizabeth H Blackburn; Stefan Wüst; Pathik D Wadhwa
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-03       Impact factor: 11.205

7.  The relationship between telomere length and clinicopathologic characteristics in colorectal cancers among Tunisian patients.

Authors:  Raja Mzahma; Maher Kharrat; Fadhel Fetiriche; Mounir Ben Moussa; Zoubeir Ben Safta; Chadli Dziri; AbdelJelil Zaouche; Habiba Chaabouni-Bouhamed
Journal:  Tumour Biol       Date:  2015-06-06

Review 8.  Biochemical markers of aging for longitudinal studies in humans.

Authors:  Peter M Engelfriet; Eugène H J M Jansen; H Susan J Picavet; Martijn E T Dollé
Journal:  Epidemiol Rev       Date:  2013-02-04       Impact factor: 6.222

9.  Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity.

Authors:  Mujib Ullah; Zhongjie Sun
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2019-08-16       Impact factor: 6.053

10.  Quantification of biological aging in young adults.

Authors:  Daniel W Belsky; Avshalom Caspi; Renate Houts; Harvey J Cohen; David L Corcoran; Andrea Danese; HonaLee Harrington; Salomon Israel; Morgan E Levine; Jonathan D Schaefer; Karen Sugden; Ben Williams; Anatoli I Yashin; Richie Poulton; Terrie E Moffitt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-06       Impact factor: 11.205
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