| Literature DB >> 23456168 |
Yongchen Hao1, Xuehui Liu, Xiangfeng Lu, Xueli Yang, Laiyuan Wang, Shufeng Chen, Hongfan Li, Jianxin Li, Jie Cao, Jichun Chen, Ying Li, Liancheng Zhao, Yongyong Shi, Chong Shen, Weili Yan, Jiang He, Jianfeng Huang, Dongfeng Gu.
Abstract
Human height is a complex genetic trait with high heritability but discovery efforts in Asian populations are limited. We carried out a meta-analysis of genome-wide association studies (GWAS) for height in 6,534 subjects with in silico replication of 1,881 subjects in Han Chinese. We identified three novel loci reaching the genome-wide significance threshold (P < 5 × 10(-8)), which mapped in or near ZNF638 (rs12612930, P = 2.02 × 10(-10)), MAML2 (rs11021504, P = 7.81 × 10(-9)), and C18orf12 (rs11082671, P = 1.87 × 10(-8)). We also confirmed two loci previously reported in European populations including CS (rs3816804, P = 2.63 × 10(-9)) and CYP19A1 (rs3751599, P = 4.80 × 10(-10)). In addition, we provided evidence supporting 35 SNPs identified by previous GWAS (P < 0.05). Our study provides new insights into the genetic determination of biological regulation of human height.Entities:
Mesh：
Year: 2013 PMID： 23456168 DOI： 10.1007/s00439-013-1280-9
Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132