BACKGROUND: Atopic dermatitis (AD) starts most often during the first years of life and goes into remission in a high proportion of cases during childhood. However, in severe cases, AD persists until adulthood or starts and relapses later in life. So far, studies investigating the natural course of AD during adolescence and adulthood are rare. The aim of our study was to classify different courses of AD and to correlate these with specific risk factors for severe variants of AD. METHODS: A detailed clinical examination and retrospective evaluation of the history of the disease were performed in a collective of 725 adolescent and adult patients with AD. Laboratory data including total and specific IgE were evaluated. RESULTS: Six hundred and seven patients of 725 patients could be classified into course types. Of these 607 patients 85.7% could be classified into five main different course types of all 31 course types recorded. The highest differences in the number of sensitizations, total immunoglobulin E serum levels and predilection of the skin lesions were observed between patients with an early type of onset of AD and a chronic persisting course until adulthood and patients with a late type of onset of AD, that is, after the 20th year of life. CONCLUSION: Our data show that the natural course of AD can be divided into subgroups that display different clinical features. The data support the assumption of a broad heterogeneity of AD in adolescence and adulthood and emphasize the future need for careful stratification of patients with AD.
BACKGROUND:Atopic dermatitis (AD) starts most often during the first years of life and goes into remission in a high proportion of cases during childhood. However, in severe cases, AD persists until adulthood or starts and relapses later in life. So far, studies investigating the natural course of AD during adolescence and adulthood are rare. The aim of our study was to classify different courses of AD and to correlate these with specific risk factors for severe variants of AD. METHODS: A detailed clinical examination and retrospective evaluation of the history of the disease were performed in a collective of 725 adolescent and adult patients with AD. Laboratory data including total and specific IgE were evaluated. RESULTS: Six hundred and seven patients of 725 patients could be classified into course types. Of these 607 patients 85.7% could be classified into five main different course types of all 31 course types recorded. The highest differences in the number of sensitizations, total immunoglobulin E serum levels and predilection of the skin lesions were observed between patients with an early type of onset of AD and a chronic persisting course until adulthood and patients with a late type of onset of AD, that is, after the 20th year of life. CONCLUSION: Our data show that the natural course of AD can be divided into subgroups that display different clinical features. The data support the assumption of a broad heterogeneity of AD in adolescence and adulthood and emphasize the future need for careful stratification of patients with AD.
Authors: Kam Lun Hon; Yin-Ching K Tsang; Terence Chuen W Poon; Nga Hin Pong; Matthew Kwan; Shirley Lau; Yuen-Chun Chiu; Hin-Hei Wong; Ting-Fan Leung Journal: World J Pediatr Date: 2015-12-18 Impact factor: 2.764
Authors: Ganesa Wegienka; Alexandra Sitarik; Gillian Bassirpour; Edward M Zoratti; Dennis Ownby; Christine C Johnson; Suzanne Havstad Journal: J Allergy Clin Immunol Pract Date: 2017-09-22
Authors: Richelle C Kosse; Marcel L Bouvy; Maud Daanen; Tjalling W de Vries; Ellen S Koster Journal: JAMA Dermatol Date: 2018-07-01 Impact factor: 10.282
Authors: Kern Rei Chng; Angeline Su Ling Tay; Chenhao Li; Amanda Hui Qi Ng; Jingjing Wang; Bani Kaur Suri; Sri Anusha Matta; Naomi McGovern; Baptiste Janela; Xuan Fei Colin C Wong; Yang Yie Sio; Bijin Veonice Au; Andreas Wilm; Paola Florez De Sessions; Thiam Chye Lim; Mark Boon Yang Tang; Florent Ginhoux; John E Connolly; E Birgitte Lane; Fook Tim Chew; John E A Common; Niranjan Nagarajan Journal: Nat Microbiol Date: 2016-07-11 Impact factor: 17.745
Authors: Katrina Abuabara; Ole Hoffstad; Andrea B Troxel; Joel M Gelfand; Charles E McCulloch; David J Margolis Journal: J Allergy Clin Immunol Date: 2017-06-17 Impact factor: 10.793
Authors: Caroline Roduit; Remo Frei; Martin Depner; Anne M Karvonen; Harald Renz; Charlotte Braun-Fahrländer; Elisabeth Schmausser-Hechfellner; Juha Pekkanen; Josef Riedler; Jean-Charles Dalphin; Erika von Mutius; Roger Pascal Lauener; Anne Hyvärinen; Pirkka Kirjavainen; Sami Remes; Marjut Roponen; Marie-Laure Dalphin; Vincent Kaulek; Markus Ege; Jon Genuneit; Sabina Illi; Micahel Kabesch; Bianca Schaub; Petra Ina Pfefferle; Gert Doekes Journal: JAMA Pediatr Date: 2017-07-01 Impact factor: 16.193