Literature DB >> 2345122

Autocrine growth factor and spontaneous transformation of rat liver epithelial cells.

T Narita1.   

Abstract

Liver epithelial cells from a young rat were cultured and passaged for a long period until they showed a malignant transformation (tumorigenicity in athymic mice), to know when an autocrine growth factor is produced in the course of a spontaneous malignant transformation of normal cells in vitro. The cells initially showed a cellular transformation and an increased growth rate, then produced an autocrine growth factor after Passage 55, and finally the cells after Passage 105 showed a malignant transformation (tumorigenicity in vivo). It is suggested that in addition to an autocrine growth factor, some other factors might be related to a malignant transformation (tumorigenicity in vivo).

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Year:  1990        PMID： 2345122     DOI： 10.1007/bf02623823

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol        ISSN： 0883-8364


  11 in total

1.  Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi.

Authors:  M WACHSTEIN; E MEISEL
Journal:  Am J Clin Pathol       Date:  1957-01       Impact factor: 2.493

2.  An 18,000 molecular weight polypeptide induces early events and stimulates DNA synthesis in cultured cells.

Authors:  H R Bourne; E Rozengurt
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

Review 3.  Tumor angiogenesis.

Authors:  J Folkman
Journal:  Adv Cancer Res       Date:  1974       Impact factor: 6.242

4.  Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity.

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Journal:  J Histochem Cytochem       Date:  1969-08       Impact factor: 2.479

5.  Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

Authors:  G J Todaro; C Fryling; J E De Larco
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

6.  Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor.

Authors:  C H Heldin; B Westermark; A Wasteson
Journal:  J Cell Physiol       Date:  1980-11       Impact factor: 6.384

7.  Production of growth factors by human myeloma cells.

Authors:  B Klein; M Jourdan; A Vazquez; B Dugas; R Bataille
Journal:  Cancer Res       Date:  1987-09-15       Impact factor: 12.701

8.  Partial purification of a growth factor synthesized by a rat hepatoma cell line established in serum-free medium.

Authors:  H Matsuda; M Matsumoto; S Haraguchi; K Kanai
Journal:  Cancer Res       Date:  1989-04-15       Impact factor: 12.701

9.  Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.

Authors:  R F Doolittle; M W Hunkapiller; L E Hood; S G Devare; K C Robbins; S A Aaronson; H N Antoniades
Journal:  Science       Date:  1983-07-15       Impact factor: 47.728

10.  Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.

Authors:  M D Waterfield; G T Scrace; N Whittle; P Stroobant; A Johnsson; A Wasteson; B Westermark; C H Heldin; J S Huang; T F Deuel
Journal:  Nature       Date:  1983 Jul 7-13       Impact factor: 49.962
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  3 in total

1.  The stem cells of the liver--a selective review.

Authors:  K Aterman
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

2.  Development and characterization of a rainbow trout liver cell line expressing cytochrome P450-dependent monooxygenase activity.

Authors:  L E Lee; J H Clemons; D G Bechtel; S J Caldwell; K B Han; M Pasitschniak-Arts; D D Mosser; N C Bols
Journal:  Cell Biol Toxicol       Date:  1993 Jul-Sep       Impact factor: 6.691

3.  Species-specific differences in the mitogenic activity of heparin-binding growth factors in the sera of various mammals.

Authors:  Y Yonezawa; H Kondo; R Hirai; K Kaji; K Nishikawa
Journal:  Experientia       Date:  1992-03-15
  3 in total

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