Literature DB >> 6306471

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.

M D Waterfield, G T Scrace, N Whittle, P Stroobant, A Johnsson, A Wasteson, B Westermark, C H Heldin, J S Huang, T F Deuel.   

Abstract

A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.

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Year:  1983        PMID： 6306471     DOI： 10.1038/304035a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  321 in total

1.  Classical oncogenes and tumor suppressor genes: a comparative genomics perspective.

Authors:  O K Pickeral; J Z Li; I Barrow; M S Boguski; W Makałowski; J Zhang
Journal:  Neoplasia       Date:  2000 May-Jun       Impact factor: 5.715

2.  Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin.

Authors:  A Smits; K Funa; F S Vassbotn; M Beausang-Linder; F af Ekenstam; C H Heldin; B Westermark; M Nistér
Journal:  Am J Pathol       Date:  1992-03       Impact factor: 4.307

Review 3.  Monoclonal antibodies to epidermal growth factor receptors in studies of receptor structure and function.

Authors:  T Kawamoto; G H Sato; K Takahashi; M Nishi; S Taniguchi; J D Sato
Journal:  Cytotechnology       Date:  1990-05       Impact factor: 2.058

Review 4.  Mouse chromosome 15.

Authors:  B A Mock; P E Neumann; J T Eppig; K E Huppi
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

5.  Recent developments in the structure, function and regulation of platelet-derived growth factor and its receptors.

Authors:  J Tiesman; A Rizzino
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

Review 6.  The ERBB network: at last, cancer therapy meets systems biology.

Authors:  Yosef Yarden; Gur Pines
Journal:  Nat Rev Cancer       Date:  2012-07-12       Impact factor: 60.716

Review 7.  Roles for growth factors in cancer progression.

Authors:  Esther Witsch; Michael Sela; Yosef Yarden
Journal:  Physiology (Bethesda)       Date:  2010-04

8.  Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

Authors:  T Matsui; J H Pierce; T P Fleming; J S Greenberger; W J LaRochelle; M Ruggiero; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

Review 9.  Heterogeneity of human colon carcinoma.

Authors:  M G Brattain; A E Levine; S Chakrabarty; L C Yeoman; J K Willson; B Long
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

10.  Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences.

Authors:  L Ratner; B Thielan; T Collins
Journal:  Nucleic Acids Res       Date:  1987-08-11       Impact factor: 16.971
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