Maria Zulfiqar1, David M Yousem, Hong Lai. 1. The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institution, 600 N Wolfe St, Phipps B100F, Baltimore, MD 21287, USA.
Abstract
OBJECTIVE: The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS: Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS: The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and < 0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION: Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.
OBJECTIVE: The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS: Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS: The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and < 0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION: Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.
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