Literature DB >> 23436619

Design of libraries targeting protein-protein interfaces.

David Fry1, Kuo-Sen Huang, Paola Di Lello, Peter Mohr, Klaus Müller, Sung-Sau So, Takeo Harada, Martin Stahl, Binh Vu, Harald Mauser.   

Abstract

TARGETING PPIS: A novel strategy for designing libraries targeting protein-protein interfaces enabled us to identify diverse chemical entry points to interact with therapeutic targets for which conventional screening libraries delivered no or only few hit structures. The concept was experimentally validated by early hit evaluation in biochemical screens and early ADMET profiling.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23436619     DOI： 10.1002/cmdc.201200540

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  8 in total

1.  2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

Authors:  Véronique Hamon; Raphael Bourgeas; Pierre Ducrot; Isabelle Theret; Laura Xuereb; Marie Jeanne Basse; Jean Michel Brunel; Sebastien Combes; Xavier Morelli; Philippe Roche
Journal:  J R Soc Interface       Date:  2013-11-06       Impact factor: 4.118

Review 2.  Oncogenic protein interfaces: small molecules, big challenges.

Authors:  Tracy L Nero; Craig J Morton; Jessica K Holien; Jerome Wielens; Michael W Parker
Journal:  Nat Rev Cancer       Date:  2014-03-13       Impact factor: 60.716

Review 3.  Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design.

Authors:  Sitanshu S Singh; Seetharama D Jois
Journal:  Adv Protein Chem Struct Biol       Date:  2017-10-06       Impact factor: 3.507

Review 4.  Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology.

Authors:  Bruno O Villoutreix; Melaine A Kuenemann; Jean-Luc Poyet; Heriberto Bruzzoni-Giovanelli; Céline Labbé; David Lagorce; Olivier Sperandio; Maria A Miteva
Journal:  Mol Inform       Date:  2014-06-02       Impact factor: 3.353

5.  Synthesis of Terpyridines: Simple Reactions-What Could Possibly Go Wrong?

Authors:  Dalila Rocco; Catherine E Housecroft; Edwin C Constable
Journal:  Molecules       Date:  2019-05-09       Impact factor: 4.411

Review 6.  Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.

Authors:  Luca Laraia; Grahame McKenzie; David R Spring; Ashok R Venkitaraman; David J Huggins
Journal:  Chem Biol       Date:  2015-06-18

7.  An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces.

Authors:  Masakazu Nakadai; Shuta Tomida; Kazuhisa Sekimizu
Journal:  Sci Rep       Date:  2016-01-04       Impact factor: 4.379

8.  Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors.

Authors:  Mélaine A Kuenemann; Céline M Labbé; Adrien H Cerdan; Olivier Sperandio
Journal:  Sci Rep       Date:  2016-04-01       Impact factor: 4.379
  8 in total

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