Literature DB >> 23435376

MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2.

Qunyan Yao1, Zhongwei Cao, Chuantao Tu, Yuan Zhao, Hongchun Liu, Shuncai Zhang.   

Abstract

Previous studies have shown that miR-146a acts as either an oncogene or a tumor suppressor in various cancers. In this study, we investigated the role of miR-146a in gastric cancer cells and its potential target genes. The results showed that miR-146a expression correlated inversely with WASF2 protein expression in gastric cancer cell lines. Overexpression of miR-146a suppressed the migration and invasion of gastric cancer cells, and also the protein level of WASF2. WASF2 was shown to be a direct target gene of miR-146a by luciferase assays. Restoration of WASF2 promoted the migration and invasion of gastric cancer cells, similar to that mediated by miR-146a inhibition. This study has identified an onco-suppressive role of miR-146a in gastric cancer cells by its reduction of WASF2 expression. The newly identified miR-146a/WASF2 axis partially reveals the molecular mechanism underlying the migration and invasion of gastric cancer cells and represents a new potential therapeutic target for gastric cancer.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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Year:  2013        PMID： 23435376     DOI： 10.1016/j.canlet.2013.02.031

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  47 in total

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Authors:  Liming Xie; Zhiwei Zhang; Zhiqin Tan; Rongfang He; Xi Zeng; Yuanjie Xie; Suyun Li; Guohua Tang; Hailin Tang; Xiusheng He
Journal:  Mol Cell Biochem       Date:  2014-07       Impact factor: 3.396

2.  Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status.

Authors:  Rupninder Sandhu; Jessica Rein; Monica D'Arcy; Jason I Herschkowitz; Katherine A Hoadley; Melissa A Troester
Journal:  Carcinogenesis       Date:  2014-08-14       Impact factor: 4.944

Review 3.  MicroRNA and signaling pathways in gastric cancer.

Authors:  Z Zhang; Z Li; Y Li; A Zang
Journal:  Cancer Gene Ther       Date:  2014-07-25       Impact factor: 5.987

4.  Expression profiles of miR-196, miR-132, miR-146a, and miR-134 in human colorectal cancer tissues in accordance with their clinical significance : Comparison regarding KRAS mutation.

Authors:  Mahafarin Maralani; Dariush Shanehbandi; Milad Asadi; Shahriar Hashemzadeh; Khalil Hajiasgharzadeh; Hossein Mashhadi Abdolahi; Behzad Baradaran; Marc Peeters
Journal:  Wien Klin Wochenschr       Date:  2021-08-31       Impact factor: 1.704

5.  Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis.

Authors:  Yunfei Zuo; Shuangyi Ren; Yinan Zhang; Zhen Feng; Yue Xu; Sufen Jiang; Qianshi Zhang; Zhenyu Zhang; Keyong Wang; Xiaomeng Li; Lijie Xu; Menglang Yuan; Zihao Chen; Jingyi Cui; Han Wu; Yina Gao; Wei Wei; Bo Wang
Journal:  Cell Death Dis       Date:  2022-07-11       Impact factor: 9.685

6.  Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population.

Authors:  Guo-Liang Huang; Mei-Ling Chen; Ya-Zhen Li; Yan Lu; Xing-Xiang Pu; Yu-Xiang He; Shu-Yin Tang; Hua Che; Ying Zou; Congcong Ding; Zhiwei He
Journal:  J Hum Genet       Date:  2014-01-16       Impact factor: 3.172

7.  MiR-185 acts as a tumor suppressor by targeting AKT1 in non-small cell lung cancer cells.

Authors:  Shuai Li; Yulian Ma; Xinfang Hou; Ying Liu; Ke Li; Shuning Xu; Jufeng Wang
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

8.  Association of a genetic variant in microRNA-146a with risk of colorectal cancer: a population-based case-control study.

Authors:  Yingying Mao; Yingjun Li; Fangyuan Jing; Shaofang Cai; Zhenyu Zhang; Qilong Li; Xinyuan Ma; Jianbing Wang; Mingjuan Jin; Kun Chen
Journal:  Tumour Biol       Date:  2014-04-17

9.  Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling.

Authors:  Shadan Ali; Aamir Ahmad; Amro Aboukameel; Alia Ahmed; Bin Bao; Sanjeev Banerjee; Philip A Philip; Fazlul H Sarkar
Journal:  Cancer Lett       Date:  2014-05-16       Impact factor: 8.679

Review 10.  Dysregulation of non-coding RNAs in gastric cancer.

Authors:  Qing Yang; Ren-Wen Zhang; Peng-Cheng Sui; Hai-Tao He; Lei Ding
Journal:  World J Gastroenterol       Date:  2015-10-21       Impact factor: 5.742
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