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Literature DB >> 23434068

Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.

Samy Lamouille¹, Deepa Subramanyam, Robert Blelloch, Rik Derynck.

Abstract

Epithelial-mesenchymal transition (EMT) and the reverse process, mesenchymal-epithelial transition (MET), are essential during development and in the regulation of stem cell pluripotency, yet these processes are also activated in pathological contexts, such as in fibrosis and cancer progression. In EMT and MET, diverse signaling pathways cooperate in the initiation and progression of the EMT and MET programs, through regulation at transcriptional, post-transcriptional, translational, and post-translational levels. MicroRNAs recently emerged as potent regulators of EMT and MET, with their abilities to target multiple components involved in epithelial integrity or mesenchymal traits. By affecting EMT and MET processes, microRNAs are involved in the regulation of stem cell pluripotency and the control of tumor progression.

Entities: CellLine Chemical Disease Gene Species

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Year: 2013 PMID： 23434068 PMCID： PMC4240277 DOI： 10.1016/j.ceb.2013.01.008

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

52 in total

1. miRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signaling.

Authors: Peng Ru; Robert Steele; Philip Newhall; Nancy J Phillips; Karoly Toth; Ratna B Ray
Journal: Mol Cancer Ther Date: 2012-03-08 Impact factor: 6.261

2. MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1.

Authors: L Sun; Y Yao; B Liu; Z Lin; L Lin; M Yang; W Zhang; W Chen; C Pan; Q Liu; E Song; J Li
Journal: Oncogene Date: 2011-07-04 Impact factor: 9.867

3. Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.

Authors: E Papadimitriou; E Vasilaki; C Vorvis; D Iliopoulos; A Moustakas; D Kardassis; C Stournaras
Journal: Oncogene Date: 2011-10-10 Impact factor: 9.867

4. MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1.

Authors: Ji Qi; Shawn J Rice; Anna C Salzberg; E Aaron Runkle; Jason Liao; Dani S Zander; David Mu
Journal: Cell Cycle Date: 2012-01-01 Impact factor: 4.534

5. Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells.

Authors: Mingli Han; Manran Liu; Yimeng Wang; Zhiqiang Mo; Xiaokai Bi; Zhirong Liu; Yuanming Fan; Xin Chen; Chengyi Wu
Journal: Mol Cell Biochem Date: 2011-12-21 Impact factor: 3.396

6. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.

Authors: Helge Siemens; Rene Jackstadt; Sabine Hünten; Markus Kaller; Antje Menssen; Ursula Götz; Heiko Hermeking
Journal: Cell Cycle Date: 2011-12-15 Impact factor: 4.534

7. MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways.

Authors: I Keklikoglou; C Koerner; C Schmidt; J D Zhang; D Heckmann; A Shavinskaya; H Allgayer; B Gückel; T Fehm; A Schneeweiss; O Sahin; S Wiemann; U Tschulena
Journal: Oncogene Date: 2011-12-12 Impact factor: 9.867

8. Inverse association between miR-194 expression and tumor invasion in gastric cancer.

Authors: Yongxi Song; Feng Zhao; Zhenning Wang; Zhuangkai Liu; Yeunpo Chiang; Yingying Xu; Peng Gao; Huimian Xu
Journal: Ann Surg Oncol Date: 2011-08-16 Impact factor: 5.344

9. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN.

Authors: Mingli Han; Manran Liu; Yimeng Wang; Xin Chen; Jianli Xu; Yan Sun; Liuyang Zhao; Hongbo Qu; Yuanming Fan; Chengyi Wu
Journal: PLoS One Date: 2012-06-25 Impact factor: 3.240

10. A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition.

Authors: Michèle Moes; Antony Le Béchec; Isaac Crespo; Christina Laurini; Aliaksandr Halavatyi; Guillaume Vetter; Antonio Del Sol; Evelyne Friederich
Journal: PLoS One Date: 2012-04-13 Impact factor: 3.240

116 in total

1. Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro.

Authors: Isabele C Iser; Stefanie M Ceschini; Giovana R Onzi; Ana Paula S Bertoni; Guido Lenz; Márcia R Wink
Journal: Mol Neurobiol Date: 2015-12-19 Impact factor: 5.590

Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.

1. miRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signaling.

2. MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1.

3. Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.

4. MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1.

5. Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells.

6. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.

7. MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways.

8. Inverse association between miR-194 expression and tumor invasion in gastric cancer.

9. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN.

10. A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition.

1. Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro.

Review 2. The role of microRNAs in skin fibrosis.

Review 3. TGFβ biology in cancer progression and immunotherapy.

Review 4. RNA viruses and microRNAs: challenging discoveries for the 21st century.

Review 5. The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms.

Review 6. MicroRNAs as novel regulators of stem cell fate.

7. miR-8 modulates cytoskeletal regulators to influence cell survival and epithelial organization in Drosophila wings.

8. microRNA-375 inhibits osteogenic differentiation by targeting runt-related transcription factor 2.

Review 9. MicroRNAs in the control of metastatic bone disease.

Review 10. Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer.