Literature DB >> 24158354

The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms.

Yue Teng1, Xu Li.   

Abstract

Epithelial-to-mesenchymal transition (EMT) is presently recognized as an important event and the initiating stage for tumor invasion and metastasis. Several EMT inducers have been identified, among which the big family of helix-loop-helix (HLH) transcription factors are rising as a novel and promising family of proteins in EMT mediation, such as Twist1, Twist2, E47, and HIFs, etc. Due to the variety and complexities of HLH members, the pathways and mechanisms they employ to promote EMT are also complex and characteristic. In this review, we will discuss the roles of various HLH proteins in the regulation and sustenance of the EMT and multiple cellular mechanisms, attempting to provide a novel and broadened view towards the link between HLH proteins and EMT.

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Year:  2013        PMID： 24158354     DOI： 10.1007/s10585-013-9621-6

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  108 in total

1.  Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.

Authors:  Yingjian Li; Junwei Yang; Jian-Hua Luo; Shoukat Dedhar; Youhua Liu
Journal:  J Am Soc Nephrol       Date:  2007-01-03       Impact factor: 10.121

Review 2.  Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

Authors:  Héctor Peinado; David Olmeda; Amparo Cano
Journal:  Nat Rev Cancer       Date:  2007-05-17       Impact factor: 60.716

3.  Sim1 and Sim2 are required for the correct targeting of mammillary body axons.

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Journal:  Development       Date:  2005-11-16       Impact factor: 6.868

Review 4.  Regulatory networks defining EMT during cancer initiation and progression.

Authors:  Bram De Craene; Geert Berx
Journal:  Nat Rev Cancer       Date:  2013-02       Impact factor: 60.716

5.  Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.

Authors:  Andreas Fischer; Christian Steidl; Toni U Wagner; Esra Lang; Peter M Jakob; Peter Friedl; Klaus-Peter Knobeloch; Manfred Gessler
Journal:  Circ Res       Date:  2007-02-15       Impact factor: 17.367

6.  Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells.

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Journal:  Int J Mol Med       Date:  2011-02-14       Impact factor: 4.101

7.  Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.

Authors:  Guofei Zhou; Laura A Dada; Minghua Wu; Aileen Kelly; Humberto Trejo; Qiyuan Zhou; John Varga; Jacob I Sznajder
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2009-10-02       Impact factor: 5.464

8.  Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.

Authors:  Manav Korpal; Brian J Ell; Francesca M Buffa; Toni Ibrahim; Mario A Blanco; Toni Celià-Terrassa; Laura Mercatali; Zia Khan; Hani Goodarzi; Yuling Hua; Yong Wei; Guohong Hu; Benjamin A Garcia; Jiannis Ragoussis; Dino Amadori; Adrian L Harris; Yibin Kang
Journal:  Nat Med       Date:  2011-08-07       Impact factor: 53.440

9.  Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics.

Authors:  Elena Simionato; Valérie Ledent; Gemma Richards; Morgane Thomas-Chollier; Pierre Kerner; David Coornaert; Bernard M Degnan; Michel Vervoort
Journal:  BMC Evol Biol       Date:  2007-03-02       Impact factor: 3.260

10.  miR-200 enhances mouse breast cancer cell colonization to form distant metastases.

Authors:  Derek M Dykxhoorn; Yichao Wu; Huangming Xie; Fengyan Yu; Ashish Lal; Fabio Petrocca; Denis Martinvalet; Erwei Song; Bing Lim; Judy Lieberman
Journal:  PLoS One       Date:  2009-09-29       Impact factor: 3.240
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  22 in total

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Authors:  Thomas J Lynch; Preston J Anderson; Pavana G Rotti; Scott R Tyler; Adrianne K Crooke; Soon H Choi; Daniel T Montoro; Carolyn L Silverman; Weam Shahin; Rui Zhao; Chandler W Jensen-Cody; Andrea Adamcakova-Dodd; T Idil Apak Evans; Weiliang Xie; Yulong Zhang; Hongmei Mou; B Paul Herring; Peter S Thorne; Jayaraj Rajagopal; Charles Yeaman; Kalpaj R Parekh; John F Engelhardt
Journal:  Cell Stem Cell       Date:  2018-04-12       Impact factor: 24.633

Review 2.  Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.

Authors:  Reem Malek; Hailun Wang; Kekoa Taparra; Phuoc T Tran
Journal:  Cells Tissues Organs       Date:  2017-02-20       Impact factor: 2.481

Review 3.  Regulation of the protein stability of EMT transcription factors.

Authors:  V M Díaz; R Viñas-Castells; A García de Herreros
Journal:  Cell Adh Migr       Date:  2014       Impact factor: 3.405

4.  Introduction of revised "Aims and Scope" for Clinical & Experimental Metastasis.

Authors:  Jonathan P Sleeman
Journal:  Clin Exp Metastasis       Date:  2016-12       Impact factor: 5.150

5.  Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes.

Authors:  Shannon Marchegiani; Taylor Davis; Federico Tessadori; Gijs van Haaften; Francesco Brancati; Alexander Hoischen; Haigen Huang; Elise Valkanas; Barbara Pusey; Denny Schanze; Hanka Venselaar; Anneke T Vulto-van Silfhout; Lynne A Wolfe; Cynthia J Tifft; Patricia M Zerfas; Giovanna Zambruno; Ariana Kariminejad; Farahnaz Sabbagh-Kermani; Janice Lee; Maria G Tsokos; Chyi-Chia R Lee; Victor Ferraz; Eduarda Morgana da Silva; Cathy A Stevens; Nathalie Roche; Oliver Bartsch; Peter Farndon; Eva Bermejo-Sanchez; Brian P Brooks; Valerie Maduro; Bruno Dallapiccola; Feliciano J Ramos; Hon-Yin Brian Chung; Cédric Le Caignec; Fabiana Martins; Witold K Jacyk; Laura Mazzanti; Han G Brunner; Jeroen Bakkers; Shuo Lin; May Christine V Malicdan; Cornelius F Boerkoel; William A Gahl; Bert B A de Vries; Mieke M van Haelst; Martin Zenker; Thomas C Markello
Journal:  Am J Hum Genet       Date:  2015-06-25       Impact factor: 11.025

6.  Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension.

Authors:  Kel Vin Woo; Isabel Y Shen; Carla J Weinheimer; Attila Kovacs; Jessica Nigro; Chieh-Yu Lin; Murali Chakinala; Derek E Byers; David M Ornitz
Journal:  J Clin Invest       Date:  2021-09-01       Impact factor: 14.808

7.  Anterior segment dysgenesis correlation with epithelial-mesenchymal transition in Smad4 knockout mice.

Authors:  Jing Li; Yu Qin; Fang-Kun Zhao; Di Wu; Xue-Fei He; Jia Liu; Jiang-Yue Zhao; Jin-Song Zhang
Journal:  Int J Ophthalmol       Date:  2016-07-18       Impact factor: 1.779

8.  PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.

Authors:  G Zhu; X Li; B Guo; Q Ke; M Dong; F Li
Journal:  Oncogene       Date:  2015-07-27       Impact factor: 9.867

9.  Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden.

Authors:  James Finlay; Cai M Roberts; Juyao Dong; Jeffrey I Zink; Fuyuhiko Tamanoi; Carlotta A Glackin
Journal:  Nanomedicine       Date:  2015-06-24       Impact factor: 5.307

10.  Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt Activation.

Authors:  Yong-Qu Zhang; Xiao-Long Wei; Yuan-Ke Liang; Wei-Ling Chen; Fan Zhang; Jing-Wen Bai; Si-Qi Qiu; Cai-Wen Du; Wen-He Huang; Guo-Jun Zhang
Journal:  PLoS One       Date:  2015-08-21       Impact factor: 3.240
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