BACKGROUND: Diabetes is associated with increased risk of a spectrum of cancers, but there are few meta-analyses on the association between diabetes and kidney cancer. We performed a meta-analysis of case-control studies and cohort studies to address the incidence and mortality of kidney cancer in diabetes. METHODS: Studies were identified by searching PubMed database and manual assessment of the cited references in the retrieved articles. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a random-effect model. Study quality was assessed using the Newcastle-Ottawa scale. RESULTS: A total of 24 studies were included. We found that diabetes was significantly associated with increased risk of kidney cancer (RR=1.40, 95% CI=1.16 to 1.69), and the results were consistent between case-control and cohort studies. A slightly stronger positive relation was observed in women (RR=1.47, 95% CI=1.18 to 1.83) than in men (RR=1.28, 95% CI=1.10 to 1.48). Additional analyses indicated that the increased risk of kidney cancer was independent of alcohol consumption, body mass index (BMI)/obesity and smoking. However, there was no association between diabetes and mortality of kidney cancer (RR=1.12, 95% CI=0.99 to 1.20), without heterogeneity (P=0.419, I(2)=1.8%). CONCLUSIONS: Diabetes mellitus may increase the risk of kidney cancer in both women and men.
BACKGROUND:Diabetes is associated with increased risk of a spectrum of cancers, but there are few meta-analyses on the association between diabetes and kidney cancer. We performed a meta-analysis of case-control studies and cohort studies to address the incidence and mortality of kidney cancer in diabetes. METHODS: Studies were identified by searching PubMed database and manual assessment of the cited references in the retrieved articles. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a random-effect model. Study quality was assessed using the Newcastle-Ottawa scale. RESULTS: A total of 24 studies were included. We found that diabetes was significantly associated with increased risk of kidney cancer (RR=1.40, 95% CI=1.16 to 1.69), and the results were consistent between case-control and cohort studies. A slightly stronger positive relation was observed in women (RR=1.47, 95% CI=1.18 to 1.83) than in men (RR=1.28, 95% CI=1.10 to 1.48). Additional analyses indicated that the increased risk of kidney cancer was independent of alcohol consumption, body mass index (BMI)/obesity and smoking. However, there was no association between diabetes and mortality of kidney cancer (RR=1.12, 95% CI=0.99 to 1.20), without heterogeneity (P=0.419, I(2)=1.8%). CONCLUSIONS:Diabetes mellitus may increase the risk of kidney cancer in both women and men.
Authors: Madhur Nayan; Antonio Finelli; Michael A S Jewett; David N Juurlink; Peter C Austin; Girish S Kulkarni; Robert J Hamilton Journal: Endocrine Date: 2016-11-04 Impact factor: 3.633
Authors: Rebecca E Graff; Alejandro Sanchez; Deirdre K Tobias; Dayron Rodríguez; Glen W Barrisford; Michael L Blute; Yanping Li; Qi Sun; Mark A Preston; Kathryn M Wilson; Eunyoung Cho Journal: Diabetes Care Date: 2018-04-20 Impact factor: 19.112
Authors: Shuo Wang; Mark D Lo Galbo; Cindy Blair; Bharat Thyagarajan; Kristin E Anderson; DeAnn Lazovich; Anna Prizment Journal: Maturitas Date: 2020-08-11 Impact factor: 4.342