Shuo Wang1, Mark D Lo Galbo2, Cindy Blair3, Bharat Thyagarajan4, Kristin E Anderson5, DeAnn Lazovich5, Anna Prizment6. 1. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, United States. 2. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, United States; Children's Minnesota, Minneapolis, MN, United States. 3. Department of Internal Medicine, University of New Mexico, United States; University of New Mexico Comprehensive Cancer Center, United States. 4. Masonic Cancer Center, University of Minnesota, United States; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, United States. 5. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, United States; Masonic Cancer Center, University of Minnesota, United States. 6. Masonic Cancer Center, University of Minnesota, United States; Division of Hematology, Oncology and Transplantation, Medical School, University of Minnesota, United States. Electronic address: prizm001@umn.edu.
Abstract
BACKGROUND: Many studies have reported a positive association between diabetes and kidney cancer. However, it is unclear whether diabetes is a risk factor for kidney cancer independent of other risk factors, such as obesity and hypertension. We comprehensively examined the association of diabetes and its duration with incident kidney cancer in the prospective cohort Iowa Women's Health Study (1986-2011). METHODS: Diabetes status was self-reported at baseline (1986) and on five follow-up questionnaires. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of baseline and time-dependent diabetes with the risk of incident kidney cancer. RESULTS: During the 25 years of follow-up, 245 cases of kidney cancer occurred among 36,975 post-menopausal women. In an age-adjusted model, there was a significant association between time-dependent diabetes and the risk of kidney cancer [HR (95% CI) = 1.76 (1.26, 1.45)]; the association was attenuated after multivariable adjustment for age, body mass index (BMI), waist-to-hip ratio (WHR), hypertension, physical activity, diuretic use, pack-years of smoking, alcohol intake, and total caloric intake [HR = 1.35 (0.94, 1.94)]. However, among non-obese women or women with a waist circumference less than 34.6 in., diabetes was significantly associated with kidney cancer risk: for time-dependent diabetes, HRs (95% CIs) were 1.82 (1.10, 3.00) among those with BMI < 30 kg/m2 and 2.18 (1.08, 4.38) among those with a waist circumference <34.6 in.. CONCLUSIONS: Our results suggest that diabetes is associated with kidney cancer risk among non-obese post-menopausal women.
BACKGROUND: Many studies have reported a positive association between diabetes and kidney cancer. However, it is unclear whether diabetes is a risk factor for kidney cancer independent of other risk factors, such as obesity and hypertension. We comprehensively examined the association of diabetes and its duration with incident kidney cancer in the prospective cohort Iowa Women's Health Study (1986-2011). METHODS: Diabetes status was self-reported at baseline (1986) and on five follow-up questionnaires. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of baseline and time-dependent diabetes with the risk of incident kidney cancer. RESULTS: During the 25 years of follow-up, 245 cases of kidney cancer occurred among 36,975 post-menopausal women. In an age-adjusted model, there was a significant association between time-dependent diabetes and the risk of kidney cancer [HR (95% CI) = 1.76 (1.26, 1.45)]; the association was attenuated after multivariable adjustment for age, body mass index (BMI), waist-to-hip ratio (WHR), hypertension, physical activity, diuretic use, pack-years of smoking, alcohol intake, and total caloric intake [HR = 1.35 (0.94, 1.94)]. However, among non-obese women or women with a waist circumference less than 34.6 in., diabetes was significantly associated with kidney cancer risk: for time-dependent diabetes, HRs (95% CIs) were 1.82 (1.10, 3.00) among those with BMI < 30 kg/m2 and 2.18 (1.08, 4.38) among those with a waist circumference <34.6 in.. CONCLUSIONS: Our results suggest that diabetes is associated with kidney cancer risk among non-obese post-menopausal women.
Authors: Elizabeth A Atchison; Gloria Gridley; J Daniel Carreon; Michael F Leitzmann; Katherine A McGlynn Journal: Int J Cancer Date: 2011-02-01 Impact factor: 7.396
Authors: Chaan S Ng; Christopher G Wood; Paul M Silverman; Nizar M Tannir; Pheroze Tamboli; Carl M Sandler Journal: AJR Am J Roentgenol Date: 2008-10 Impact factor: 3.959
Authors: Michael J Davies; David J Baer; Joseph T Judd; Ellen D Brown; William S Campbell; Philip R Taylor Journal: JAMA Date: 2002-05-15 Impact factor: 56.272
Authors: Liam C Macleod; James M Hotaling; Jonathan L Wright; Michael T Davenport; John L Gore; Jonathan Harper; Emily White Journal: J Urol Date: 2013-05-09 Impact factor: 7.450
Authors: Neil Murphy; Amanda J Cross; Mustapha Abubakar; Mazda Jenab; Krasimira Aleksandrova; Marie-Christine Boutron-Ruault; Laure Dossus; Antoine Racine; Tilman Kühn; Verena A Katzke; Anne Tjønneland; Kristina E N Petersen; Kim Overvad; J Ramón Quirós; Paula Jakszyn; Esther Molina-Montes; Miren Dorronsoro; José-María Huerta; Aurelio Barricarte; Kay-Tee Khaw; Nick Wareham; Ruth C Travis; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Paolo Vineis; Salvatore Panico; H Bas Bueno-de-Mesquita; Peter D Siersema; Petra H Peeters; Bodil Ohlsson; Ulrika Ericson; Richard Palmqvist; Hanna Nyström; Elisabete Weiderpass; Guri Skeie; Heinz Freisling; So Yeon Kong; Kostas Tsilidis; David C Muller; Elio Riboli; Marc J Gunter Journal: PLoS Med Date: 2016-04-05 Impact factor: 11.069