Literature DB >> 23432676

Fibroblast growth factor-2, bone homeostasis and fracture repair.

Yurong Fei1, Gloria Gronowicz, Marja M Hurley.   

Abstract

There remains a great need to develop therapeutic agents to treat critical size defects and non-union fractures and one of the potential agents is recombinant human fibroblast growth factor 2 (FGF-2). We discuss the function of FGF-2 in bone formation, bone resorption, and downstream signaling pathways and review the role of exogenous FGF-2 in fracture healing. The importance of endogenous FGF-2 in bone formation and its potential importance in fracture healing in response to parathyroid hormone (PTH) and bone morphogenetic protein 2 (BMP2) is described. In addition we will review, FGF-2 signaling crosstalk with Wnt signaling and PTH signaling in bone formation and repair. Finally, we discuss the outstanding unresolved issues in the application of FGF-2 as therapeutic agent for bone regeneration.

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Year:  2013        PMID： 23432676     DOI： 10.2174/1381612811319190002

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  20 in total

1.  [Experimental study on accelerated healing of jaw fracture using gelatin sponge compound growth factor].

Authors:  Tang Yanfeng; Chen Jianlin; Zhou Yunbiao
Journal:  Hua Xi Kou Qiang Yi Xue Za Zhi       Date:  2017-10-01

Review 2.  Fracture healing: mechanisms and interventions.

Authors:  Thomas A Einhorn; Louis C Gerstenfeld
Journal:  Nat Rev Rheumatol       Date:  2014-09-30       Impact factor: 20.543

3.  * Calvarial Bone Regeneration Is Enhanced by Sequential Delivery of FGF-2 and BMP-2 from Layer-by-Layer Coatings with a Biomimetic Calcium Phosphate Barrier Layer.

Authors:  Gloria Gronowicz; Emily Jacobs; Tao Peng; Li Zhu; Marja Hurley; Liisa T Kuhn
Journal:  Tissue Eng Part A       Date:  2017-11-13       Impact factor: 3.845

Review 4.  Osteocytogenesis: Roles of Physicochemical Factors, Collagen Cleavage, and Exogenous Molecules.

Authors:  Xuening Chen; Lichen Wang; Kaitao Zhao; Hongjun Wang
Journal:  Tissue Eng Part B Rev       Date:  2018-01-05       Impact factor: 6.389

Review 5.  Effect of Angiogenesis in Bone Tissue Engineering.

Authors:  Jianhao Huang; Qixiu Han; Meng Cai; Jie Zhu; Lan Li; Lingfeng Yu; Zhen Wang; Gentao Fan; Yan Zhu; Jingwei Lu; Guangxin Zhou
Journal:  Ann Biomed Eng       Date:  2022-05-07       Impact factor: 3.934

Review 6.  Muscle-bone and fat-bone interactions in regulating bone mass: do PTH and PTHrP play any role?

Authors:  Nabanita S Datta
Journal:  Endocrine       Date:  2014-05-07       Impact factor: 3.633

7.  Fibroblast growth factor-2 isoform (low molecular weight/18 kDa) overexpression in preosteoblast cells promotes bone regeneration in critical size calvarial defects in male mice.

Authors:  Liping Xiao; Daisuke Ueno; Sylvain Catros; Collin Homer-Bouthiette; Lyndon Charles; Liisa Kuhn; Marja M Hurley
Journal:  Endocrinology       Date:  2014-01-09       Impact factor: 4.736

8.  Age-Related Changes in FGF-2, Fibroblast Growth Factor Receptors and β-Catenin Expression in Human Mesenchyme-Derived Progenitor Cells.

Authors:  Marja M Hurley; Gloria Gronowicz; Li Zhu; Liisa T Kuhn; Craig Rodner; Liping Xiao
Journal:  J Cell Biochem       Date:  2015-09-08       Impact factor: 4.429

Review 9.  Fibroblast growth factor signaling in skeletal development and disease.

Authors:  David M Ornitz; Pierre J Marie
Journal:  Genes Dev       Date:  2015-07-15       Impact factor: 11.361

10.  Effect of vacuum-assisted closure combined with open bone grafting to promote rabbit bone graft vascularization.

Authors:  Chao Hu; Taogen Zhang; Bin Ren; Zhouming Deng; Lin Cai; Jun Lei; Ansong Ping
Journal:  Med Sci Monit       Date:  2015-04-27
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