| Literature DB >> 35525871 |
Jianhao Huang1, Qixiu Han2, Meng Cai3, Jie Zhu2, Lan Li4, Lingfeng Yu5, Zhen Wang2, Gentao Fan6, Yan Zhu6, Jingwei Lu7,8, Guangxin Zhou9,10,11,12.
Abstract
The reconstruction of large skeletal defects is still a tricky challenge in orthopedics. The newly formed bone tissue migrates sluggishly from the periphery to the center of the scaffold due to the restrictions of exchange of oxygen and nutrition impotent cells osteogenic differentiation. Angiogenesis plays an important role in bone reconstruction and more and more studies on angiogenesis in bone tissue engineering had been published. Promising advances of angiogenesis in bone tissue engineering by scaffold designs, angiogenic factor delivery, in vivo prevascularization and in vitro prevascularization are discussed in detail. Among all the angiogenesis mode, angiogenic factor delivery is the common methods of angiogenesis in bone tissue engineering and possible research directions in the future.Entities:
Keywords: Angiogenesis; Bone tissue engineering; Cell engineering; Materials properties
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Year: 2022 PMID: 35525871 DOI: 10.1007/s10439-022-02970-9
Source DB: PubMed Journal: Ann Biomed Eng ISSN: 0090-6964 Impact factor: 3.934