Literature DB >> 23431562

Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug.

Mille B L Kryger1, Benjamin M Wohl, Anton A A Smith, Alexander N Zelikin.   

Abstract

Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT co-polymerization with acrylic acid afforded a formulation of a broad spectrum antiviral drug which avoids accumulation in erythrocytes, the origin of the main side effect of ribavirin. In cultured macrophages the macromolecular prodrugs exhibited decreased toxicity while maintaining the anti-inflammatory action of ribavirin.

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Year:  2013        PMID： 23431562     DOI： 10.1039/c3cc00315a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV.

Authors:  Anton A A Smith; Kaja Zuwala; Mille B L Kryger; Benjamin M Wohl; Carlos Guerrero-Sanchez; Martin Tolstrup; Almar Postma; Alexander N Zelikin
Journal:  Chem Sci       Date:  2014-09-16       Impact factor: 9.825

Review 2.  Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years.

Authors:  Hanadi Sinokrot; Tasneem Smerat; Anas Najjar; Rafik Karaman
Journal:  Molecules       Date:  2017-10-16       Impact factor: 4.411

3.  Macromolecular prodrugs of ribavirin: Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects.

Authors:  Kaja Zuwala; Camilla F Riber; Kaja Borup Løvschall; Anna H F Andersen; Lise Sørensen; Paulina Gajda; Martin Tolstrup; Alexander N Zelikin
Journal:  J Control Release       Date:  2018-02-09       Impact factor: 9.776

Review 4.  Toward the prevention of coronavirus infection: what role can polymers play?

Authors:  X Jiang; Z Li; D J Young; M Liu; C Wu; Y-L Wu; X J Loh
Journal:  Mater Today Adv       Date:  2021-03-20

5.  Low-dose ribavirin treatments attenuate neuroinflammatory activation of BV-2 Cells by interfering with inducible nitric oxide synthase.

Authors:  Iva Bozic; Danijela Savic; Marija Jovanovic; Ivana Bjelobaba; Danijela Laketa; Nadezda Nedeljkovic; Mirjana Stojiljkovic; Sanja Pekovic; Irena Lavrnja
Journal:  Anal Cell Pathol (Amst)       Date:  2015-08-27       Impact factor: 2.916
  5 in total

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