PURPOSE: Physical activity is associated with a reduced risk of breast cancer development and recurrence. There are several hypothesised mechanisms for this including positive effects on metabolic and inflammatory biomarkers and favourable changes in anthropometric variables. This pilot study examined the effect of an 8-week aerobic exercise intervention on several of these outcomes, including body composition, the metabolic syndrome, C-reactive protein (CRP) and physical activity, in breast cancer survivors 2-6 months post-chemotherapy. METHODS: Assessments were completed at baseline, at 8-weeks and 3-months post-intervention. Measures taken following a 12-h fast included body composition (bioimpedance analysis), metabolic syndrome (waist circumference, blood pressure, high-density lipoprotein cholesterol, triglycerides and fasting glucose), insulin resistance (homeostatic model assessment), CRP and physical activity (accelerometry and questionnaire). Participants were randomized to either an 8-week moderate-intensity aerobic exercise group or a usual-care control group. Analysis was completed using repeated-measures analysis of variance (ANOVA) (p = 0.05). RESULTS:Twenty-six breast cancer survivors participated (mean (standard deviation) age 48.1 (8.8) years, exercise group; n = 16, control group; n = 10). At baseline, 13 participants were overweight, 6 were obese and 19 centrally obese. Intention-to-treat analysis revealed no significant differences between the exercise and control groups in any of the outcomes measures; however, analysis of those who adhered to >90 % of the supervised exercise class showed a significant decrease in waist circumference (p = 0.05) and a significant increase in subjectively reported "total weekly" (p = 0.005) activity. CONCLUSION: While this 8-week aerobic exercise pilot intervention did not elicit significant improvements in biomarkers of breast cancer risk, there was some suggestion of improvements in waist circumference and subjectively measured physical activity in participants with >90 % adherence to the programme. A trial of longer duration and greater subject numbers is warranted.
RCT Entities:
PURPOSE: Physical activity is associated with a reduced risk of breast cancer development and recurrence. There are several hypothesised mechanisms for this including positive effects on metabolic and inflammatory biomarkers and favourable changes in anthropometric variables. This pilot study examined the effect of an 8-week aerobic exercise intervention on several of these outcomes, including body composition, the metabolic syndrome, C-reactive protein (CRP) and physical activity, in breast cancer survivors 2-6 months post-chemotherapy. METHODS: Assessments were completed at baseline, at 8-weeks and 3-months post-intervention. Measures taken following a 12-h fast included body composition (bioimpedance analysis), metabolic syndrome (waist circumference, blood pressure, high-density lipoprotein cholesterol, triglycerides and fasting glucose), insulin resistance (homeostatic model assessment), CRP and physical activity (accelerometry and questionnaire). Participants were randomized to either an 8-week moderate-intensity aerobic exercise group or a usual-care control group. Analysis was completed using repeated-measures analysis of variance (ANOVA) (p = 0.05). RESULTS: Twenty-six breast cancer survivors participated (mean (standard deviation) age 48.1 (8.8) years, exercise group; n = 16, control group; n = 10). At baseline, 13 participants were overweight, 6 were obese and 19 centrally obese. Intention-to-treat analysis revealed no significant differences between the exercise and control groups in any of the outcomes measures; however, analysis of those who adhered to >90 % of the supervised exercise class showed a significant decrease in waist circumference (p = 0.05) and a significant increase in subjectively reported "total weekly" (p = 0.005) activity. CONCLUSION: While this 8-week aerobic exercise pilot intervention did not elicit significant improvements in biomarkers of breast cancer risk, there was some suggestion of improvements in waist circumference and subjectively measured physical activity in participants with >90 % adherence to the programme. A trial of longer duration and greater subject numbers is warranted.
Authors: Heather K Neilson; Christine M Friedenreich; Nigel T Brockton; Robert C Millikan Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-01 Impact factor: 4.254
Authors: Carol Ewing Garber; Bryan Blissmer; Michael R Deschenes; Barry A Franklin; Michael J Lamonte; I-Min Lee; David C Nieman; David P Swain Journal: Med Sci Sports Exerc Date: 2011-07 Impact factor: 5.411
Authors: Brigid M Lynch; David W Dunstan; Genevieve N Healy; Elisabeth Winkler; Elizabeth Eakin; Neville Owen Journal: Cancer Causes Control Date: 2009-11-01 Impact factor: 2.506
Authors: Brandon L Pierce; Marian L Neuhouser; Mark H Wener; Leslie Bernstein; Richard N Baumgartner; Rachel Ballard-Barbash; Frank D Gilliland; Kathy B Baumgartner; Bess Sorensen; Anne McTiernan; Cornelia M Ulrich Journal: Breast Cancer Res Treat Date: 2008-04-10 Impact factor: 4.872
Authors: Martine Extermann; Christiaan Leeuwenburgh; Laila Samiian; Marina Sehovic; Jinze Xu; Christopher Cubitt; Paul B Jacobsen; Marco Pahor; Stephen R Grobmyer; Todd M Manini Journal: J Geriatr Oncol Date: 2016-10-13 Impact factor: 3.599
Authors: Emer M Guinan; Suzanne L Doyle; Linda O'Neill; Margaret R Dunne; Emma K Foley; Jacintha O'Sullivan; John V Reynolds; Juliette Hussey Journal: Support Care Cancer Date: 2016-11-03 Impact factor: 3.603
Authors: Christina M Dieli-Conwright; Kerry S Courneya; Wendy Demark-Wahnefried; Nathalie Sami; Kyuwan Lee; Thomas A Buchanan; Darcy V Spicer; Debu Tripathy; Leslie Bernstein; Joanne E Mortimer Journal: J Clin Oncol Date: 2018-01-22 Impact factor: 44.544