Literature DB >> 23427246

New paradigms and future challenges in radiation oncology: an update of biological targets and technology.

Stanley L Liauw1, Philip P Connell, Ralph R Weichselbaum.   

Abstract

Radiation oncology exploits the biological interaction of radiation within tissue to promote tumor death while minimizing damage to surrounding normal tissue. The clinical delivery of radiation relies on principles of radiation physics that define how radiation energy is deposited in the body, as well as technology that facilitates accurate tumor targeting. This review will summarize the current landscape of recent biological and technological advances in radiation oncology, describe the challenges that exist, and offer potential avenues for improvement.

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Year:  2013        PMID： 23427246      PMCID： PMC3769139          DOI： 10.1126/scitranslmed.3005148

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  125 in total

1.  Pulmonary toxicity after bevacizumab and concurrent thoracic radiotherapy observed in a phase I study for inoperable stage III non-small-cell lung cancer.

Authors:  Joline S W Lind; Suresh Senan; Egbert F Smit
Journal:  J Clin Oncol       Date:  2012-02-13       Impact factor: 44.544

2.  Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma.

Authors:  Morten Hoyer; Henrik Roed; Lisa Sengelov; Anders Traberg; Lars Ohlhuis; Jorgen Pedersen; Hanne Nellemann; Anne Kiil Berthelsen; Frey Eberholst; Svend Aage Engelholm; Hans von der Maase
Journal:  Radiother Oncol       Date:  2005-07       Impact factor: 6.280

3.  Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial.

Authors:  Joseph Ragaz; Ivo A Olivotto; John J Spinelli; Norman Phillips; Stewart M Jackson; Kenneth S Wilson; Margaret A Knowling; Christopher M L Coppin; Lorna Weir; Karen Gelmon; Nhu Le; Ralph Durand; Andrew J Coldman; Mohamed Manji
Journal:  J Natl Cancer Inst       Date:  2005-01-19       Impact factor: 13.506

Review 4.  Stereotactic body radiation therapy: a novel treatment modality.

Authors:  Simon S Lo; Achilles J Fakiris; Eric L Chang; Nina A Mayr; Jian Z Wang; Lech Papiez; Bin S Teh; Ronald C McGarry; Higinia R Cardenes; Robert D Timmerman
Journal:  Nat Rev Clin Oncol       Date:  2009-12-08       Impact factor: 66.675

5.  Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial.

Authors:  M Overgaard; P S Hansen; J Overgaard; C Rose; M Andersson; F Bach; M Kjaer; C C Gadeberg; H T Mouridsen; M B Jensen; K Zedeler
Journal:  N Engl J Med       Date:  1997-10-02       Impact factor: 91.245

Review 6.  Effect of amifostine on response rates in locally advanced non-small-cell lung cancer patients treated on randomized controlled trials: a meta-analysis.

Authors:  Loren K Mell; Renuka Malik; Ritsuko Komaki; Benjamin Movsas; R Suzanne Swann; Corey Langer; Dosia Antonadou; Michael Koukourakis; Arno J Mundt
Journal:  Int J Radiat Oncol Biol Phys       Date:  2007-02-07       Impact factor: 7.038

7.  Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

Authors:  Christopher R Calabrese; Michael A Batey; Huw D Thomas; Barbara W Durkacz; Lan-Zhen Wang; Suzanne Kyle; Donald Skalitzky; Janke Li; Catherine Zhang; Theodore Boritzki; Karen Maegley; Alan H Calvert; Zdenek Hostomsky; David R Newell; Nicola J Curtin
Journal:  Clin Cancer Res       Date:  2003-07       Impact factor: 12.531

Review 8.  Radioprotection.

Authors:  Joel S Greenberger
Journal:  In Vivo       Date:  2009 Mar-Apr       Impact factor: 2.155

9.  Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Authors:  Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Maaike van den Born; Johan H van Es; Marc van de Wetering; Hans Clevers
Journal:  Science       Date:  2012-08-01       Impact factor: 47.728

10.  A restricted cell population propagates glioblastoma growth after chemotherapy.

Authors:  Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M McKay; Dennis K Burns; Steven G Kernie; Luis F Parada
Journal:  Nature       Date:  2012-08-23       Impact factor: 49.962
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  88 in total

1.  Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis.

Authors:  F Marampon; G L Gravina; C Festuccia; V M Popov; E A Colapietro; P Sanità; D Musio; F De Felice; A Lenzi; E A Jannini; E Di Cesare; V Tombolini
Journal:  J Endocrinol Invest       Date:  2015-09-03       Impact factor: 4.256

Review 2.  Association between statins and clinical outcomes among men with prostate cancer: a systematic review and meta-analysis.

Authors:  A D Raval; D Thakker; H Negi; A Vyas; H Kaur; M W Salkini
Journal:  Prostate Cancer Prostatic Dis       Date:  2016-01-19       Impact factor: 5.554

3.  Small molecule derived from a natural product that mitigates radiation injury.

Authors:  Philip P Connell; Ralph R Weichselbaum
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-01       Impact factor: 11.205

4.  Long term outcomes in the use of ileal ureter for radiation-induced ureteral strictures.

Authors:  M Francesca Monn; Joshua D Roth; Richard Bihrle; Matthew J Mellon
Journal:  Int Urol Nephrol       Date:  2018-06-15       Impact factor: 2.370

Review 5.  Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization.

Authors:  B Farhood; N H Goradel; K Mortezaee; N Khanlarkhani; E Salehi; M S Nashtaei; H Mirtavoos-Mahyari; E Motevaseli; D Shabeeb; A E Musa; M Najafi
Journal:  Clin Transl Oncol       Date:  2018-08-22       Impact factor: 3.405

Review 6.  The potential roles of bacteria to improve radiation treatment outcome.

Authors:  E Kouhsari; A Ghadimi-Daresajini; H Abdollahi; N Amirmozafari; S R Mahdavi; S Abbasian; S H Mousavi; H F Yaseri; M Moghaderi
Journal:  Clin Transl Oncol       Date:  2017-06-16       Impact factor: 3.405

Review 7.  Decreasing the Toxicity of Radiation Therapy: Radioprotectors and Radiomitigators Being Developed by the National Cancer Institute Through Small Business Innovation Research Contracts.

Authors:  Kaveh Zakeri; Deepa Narayanan; Bhadrasain Vikram; Greg Evans; C Norman Coleman; Pataje G S Prasanna
Journal:  Int J Radiat Oncol Biol Phys       Date:  2018-12-21       Impact factor: 7.038

Review 8.  Radiation-induced translational control of gene expression.

Authors:  Amy Wahba; Stacey L Lehman; Philip J Tofilon
Journal:  Translation (Austin)       Date:  2016-12-01

9.  Radioprotectors and Radiomitigators for Improving Radiation Therapy: The Small Business Innovation Research (SBIR) Gateway for Accelerating Clinical Translation.

Authors:  Pataje G S Prasanna; Deepa Narayanan; Kory Hallett; Eric J Bernhard; Mansoor M Ahmed; Gregory Evans; Bhadrasain Vikram; Michael Weingarten; C Norman Coleman
Journal:  Radiat Res       Date:  2015-08-18       Impact factor: 2.841

10.  A GSK-3β inhibitor protects against radiation necrosis in mouse brain.

Authors:  Xiaoyu Jiang; Carlos J Perez-Torres; Dinesh Thotala; John A Engelbach; Liya Yuan; Jeremy Cates; Feng Gao; Robert E Drzymala; Keith M Rich; Robert E Schmidt; Joseph J H Ackerman; Dennis E Hallahan; Joel R Garbow
Journal:  Int J Radiat Oncol Biol Phys       Date:  2014-07-15       Impact factor: 7.038
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