| Literature DB >> 23422915 |
Gordon Ramage1, Anto Jose, Leighann Sherry, David F Lappin, Brian Jones, Craig Williams.
Abstract
Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.Entities:
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Year: 2013 PMID: 23422915 PMCID: PMC3632906 DOI: 10.1128/AAC.02344-12
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191