Literature DB >> 30897959

Local delivery polymer provides sustained antifungal activity of amphotericin B with reduced cytotoxicity.

Rebecca M Haley1, Sean T Zuckerman2, Catherine A Gormley1, Julius N Korley2, Horst A von Recum1.   

Abstract

IMPACT STATEMENT: Amphotericin B (AmB) is an effective and commonly used antifungal agent. However, nephrotoxicity and poor solubility limits its usage. The proposed polymerized cyclodextrin (pCD) system therefore is an attractive method for AmB delivery, as it retains the antifungal activity of AmB while decreasing toxicity, and confining drug release to the local environment. This system could potentially be used for both prevention and treatment of established fungal infections, as AmB is toxic to fungus whether associated or released from pCD.

Entities:  

Keywords:  Drug delivery; amphotericin B; antifungal; cyclodextrin; cytotoxicity; infection

Mesh：

Substances：

Year:  2019        PMID： 30897959      PMCID： PMC6547000          DOI： 10.1177/1535370219837905

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  23 in total

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Authors:  N Singh
Journal:  Clin Infect Dis       Date:  2001-10-12       Impact factor: 9.079

2.  Cyclodextrin-based device coatings for affinity-based release of antibiotics.

Authors:  Thimma R Thatiparti; Andrew J Shoffstall; Horst A von Recum
Journal:  Biomaterials       Date:  2009-12-21       Impact factor: 12.479

3.  Low nephrotoxicity of an effective amphotericin B formulation with cationic bilayer fragments.

Authors:  Nilton Lincopan; Elsa M Mamizuka; Ana M Carmona-Ribeiro
Journal:  J Antimicrob Chemother       Date:  2005-03-10       Impact factor: 5.790

Review 4.  Cyclodextrin-based pharmaceutics: past, present and future.

Authors:  Mark E Davis; Marcus E Brewster
Journal:  Nat Rev Drug Discov       Date:  2004-12       Impact factor: 84.694

5.  Treatment of experimental visceral leishmaniasis with amphotericin B in stable albumin microspheres.

Authors:  J A Sánchez-Brunete; M A Dea; S Rama; F Bolás; J M Alunda; R Raposo; M T Méndez; S Torrado-Santiago; J J Torrado
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

6.  Pharmacokinetics of antibiotics or antifungal drugs in intensive care units.

Authors:  Guillaume Dufour; Philippe Montravers
Journal:  Curr Infect Dis Rep       Date:  2009-01       Impact factor: 3.725

7.  PHARMACOKINETIC STUDIES OF IN-SITU LIPOSOMAL PREPARATION CONTAINING AMPHOTERICIN B COMPLEXED WITH DIFFERENT CHEMICALLY MODIFIED beta-CYCLODEXTRINS.

Authors:  K K Chakraborty; S R Naik
Journal:  J Liposome Res       Date:  2001       Impact factor: 3.648

8.  Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane.

Authors:  Kosuke Shimizu; Masaaki Osada; Koji Takemoto; Yutaka Yamamoto; Tomohiro Asai; Naoto Oku
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9.  Cyclodextrin complexation for affinity-based antibiotic delivery.

Authors:  Thimma Reddy Thatiparti; Horst A von Recum
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10.  Basilar artery dissection treated by Neuroform stenting: fungal stent infection.

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1.  Microbiome: Our opponents or allies in healthcare and medicine.

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3.  Periadventitial Delivery of Simvastatin-Loaded Microparticles Attenuate Venous Neointimal Hyperplasia Associated With Arteriovenous Fistula.

Authors:  Chenglei Zhao; Sean T Zuckerman; Chuanqi Cai; Sreenivasulu Kilari; Avishek Singh; Michael Simeon; Horst A von Recum; Julius N Korley; Sanjay Misra
Journal:  J Am Heart Assoc       Date:  2020-12-05       Impact factor: 5.501

Review 4.  Research Progress on Synthesis and Application of Cyclodextrin Polymers.

Authors:  Yuan Liu; Ting Lin; Cui Cheng; Qiaowen Wang; Shujin Lin; Chun Liu; Xiao Han
Journal:  Molecules       Date:  2021-02-19       Impact factor: 4.411

5.  Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host-guest interactions in polyelectrolyte multilayer films for cancer therapy.

Authors:  Soobin Wang; Alessia Battigelli; Dahlia Alkekhia; Alexis Fairman; Valentin Antoci; Wentian Yang; Douglas Moore; Anita Shukla
Journal:  RSC Adv       Date:  2020-05-27       Impact factor: 4.036

6.  Affinity-Based Polymers Provide Long-Term Immunotherapeutic Drug Delivery Across Particle Size Ranges Optimal for Macrophage Targeting.

Authors:  Nathan A Rohner; Linda N Purdue; Horst A von Recum
Journal:  J Pharm Sci       Date:  2020-10-27       Impact factor: 3.534
  6 in total

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