PURPOSE: We evaluated optic radiation (OR) damage in patients with glaucoma by using fractional anisotropy (FA) of diffusion-tensor magnetic resonance imaging. METHODS: We studied 29 patients with glaucoma and 19 healthy controls. Regions of interest were placed over the bilateral anterior and posterior ORs on the FA maps, and the FA value of each region was measured. RESULTS: FA values of the bilateral anterior and posterior ORs were significantly lower in patients with glaucoma (anterior right, P = 0.0002; anterior left, P = 0.00028; posterior right, P = 0.0004; and posterior left, P = 0.0001) than in the healthy controls. In glaucoma patients, significant correlations were observed between the FA values and the average of the total deviation of the contralateral hemifields of both eyes (left hemifield and anterior right OR, correlation coefficient [r] = 0.46 [P = 0.013]; right hemifield and anterior left OR, r = 0.43 [P = 0.021]; left hemifield and posterior right OR, r = 0.54 [P = 0.0027]; and right hemifield and posterior left OR, r = 0.46 [P = 0.012]). CONCLUSIONS: FA values of the entire OR were decreased in glaucoma patients and correlated with the degree of visual field defect.
PURPOSE: We evaluated optic radiation (OR) damage in patients with glaucoma by using fractional anisotropy (FA) of diffusion-tensor magnetic resonance imaging. METHODS: We studied 29 patients with glaucoma and 19 healthy controls. Regions of interest were placed over the bilateral anterior and posterior ORs on the FA maps, and the FA value of each region was measured. RESULTS: FA values of the bilateral anterior and posterior ORs were significantly lower in patients with glaucoma (anterior right, P = 0.0002; anterior left, P = 0.00028; posterior right, P = 0.0004; and posterior left, P = 0.0001) than in the healthy controls. In glaucomapatients, significant correlations were observed between the FA values and the average of the total deviation of the contralateral hemifields of both eyes (left hemifield and anterior right OR, correlation coefficient [r] = 0.46 [P = 0.013]; right hemifield and anterior left OR, r = 0.43 [P = 0.021]; left hemifield and posterior right OR, r = 0.54 [P = 0.0027]; and right hemifield and posterior left OR, r = 0.46 [P = 0.012]). CONCLUSIONS: FA values of the entire OR were decreased in glaucomapatients and correlated with the degree of visual field defect.
Authors: Trevor C Wu; Elisabeth A Wilde; Erin D Bigler; Xiaoqi Li; Tricia L Merkley; Ragini Yallampalli; Stephen R McCauley; Kathleen P Schnelle; Ana C Vasquez; Zili Chu; Gerri Hanten; Jill V Hunter; Harvey S Levin Journal: Dev Neurosci Date: 2010-10-14 Impact factor: 2.984
Authors: Aditya T Hernowo; Christine C Boucard; Nomdo M Jansonius; Johanna M M Hooymans; Frans W Cornelissen Journal: Invest Ophthalmol Vis Sci Date: 2011-04-25 Impact factor: 4.799
Authors: Paolo Frezzotti; Antonio Giorgio; Ilaria Motolese; Alessandro De Leucio; Michele Iester; Eduardo Motolese; Antonio Federico; Nicola De Stefano Journal: PLoS One Date: 2014-08-27 Impact factor: 3.240
Authors: Holly D H Brown; Rachel L Woodall; Rebecca E Kitching; Heidi A Baseler; Antony B Morland Journal: Ophthalmic Physiol Opt Date: 2016-05 Impact factor: 3.117