Literature DB >> 23416387

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

Fanny L Cherblanc, Kathryn L Chapman, Robert Brown, Matthew J Fuchter.   

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Year:  2013        PMID： 23416387     DOI： 10.1038/nchembio.1187

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  8 in total

1.  Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

Authors:  Masanari Takahashi; Yasushi Takemoto; Tadahiro Shimazu; Hisashi Kawasaki; Makoto Tachibana; Yoichi Shinkai; Motoki Takagi; Kazuo Shin-ya; Yasuhiro Igarashi; Akihiro Ito; Minoru Yoshida
Journal:  J Antibiot (Tokyo)       Date:  2012-02-15       Impact factor: 2.649

Review 2.  Protein methyltransferases as a target class for drug discovery.

Authors:  Robert A Copeland; Michael E Solomon; Victoria M Richon
Journal:  Nat Rev Drug Discov       Date:  2009-09       Impact factor: 84.694

3.  On the determination of the stereochemistry of semisynthetic natural product analogues using chiroptical spectroscopy: desulfurization of epidithiodioxopiperazine fungal metabolites.

Authors:  Fanny Cherblanc; Ya-Pei Lo; Ewoud De Gussem; Laura Alcazar-Fuoli; Elaine Bignell; Yanan He; Nadine Chapman-Rothe; Patrick Bultinck; Wouter A Herrebout; Robert Brown; Henry S Rzepa; Matthew J Fuchter
Journal:  Chemistry       Date:  2011-09-05       Impact factor: 5.236

4.  Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity.

Authors:  Eriko Iwasa; Yoshitaka Hamashima; Shinya Fujishiro; Eisuke Higuchi; Akihiro Ito; Minoru Yoshida; Mikiko Sodeoka
Journal:  J Am Chem Soc       Date:  2010-03-31       Impact factor: 15.419

Review 5.  Current limitations and future opportunities for epigenetic therapies.

Authors:  F Cherblanc; N Chapman-Rothe; R Brown; M J Fuchter
Journal:  Future Med Chem       Date:  2012-03       Impact factor: 3.808

6.  Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

Authors:  Dorothea Greiner; Tiziana Bonaldi; Ragnhild Eskeland; Ernst Roemer; Axel Imhof
Journal:  Nat Chem Biol       Date:  2005-07-17       Impact factor: 15.040

7.  The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase.

Authors:  Jennifer D Tibodeau; Linda M Benson; Crescent R Isham; Whyte G Owen; Keith C Bible
Journal:  Antioxid Redox Signal       Date:  2009-05       Impact factor: 8.401

8.  Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.

Authors:  Kristina M Cook; Stephen T Hilton; Jasmin Mecinovic; William B Motherwell; William D Figg; Christopher J Schofield
Journal:  J Biol Chem       Date:  2009-07-09       Impact factor: 5.157
  8 in total
  40 in total

Review 1.  Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.

Authors:  Zhanxin Wang; Dinshaw J Patel
Journal:  Q Rev Biophys       Date:  2013-09-02       Impact factor: 5.318

Review 2.  Cellular analysis of the action of epigenetic drugs and probes.

Authors:  Mirjam Hau; Fides Zenk; A Ganesan; Nicola Iovino; Manfred Jung
Journal:  Epigenetics       Date:  2017-01-10       Impact factor: 4.528

Review 3.  Inhibitors of Protein Methyltransferases and Demethylases.

Authors:  H Ümit Kaniskan; Michael L Martini; Jian Jin
Journal:  Chem Rev       Date:  2017-03-24       Impact factor: 60.622

4.  Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases".

Authors:  Dorothea Greiner; Tiziana Bonaldi; Ragnhild Eskeland; Ernst Roemer; Axel Imhof
Journal:  Nat Chem Biol       Date:  2013-03       Impact factor: 15.040

5.  High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

Authors:  Nathan P Coussens; Stephen C Kales; Mark J Henderson; Olivia W Lee; Kurumi Y Horiuchi; Yuren Wang; Qing Chen; Ekaterina Kuznetsova; Jianghong Wu; Sirisha Chakka; Dorian M Cheff; Ken Chih-Chien Cheng; Paul Shinn; Kyle R Brimacombe; Min Shen; Anton Simeonov; Madhu Lal-Nag; Haiching Ma; Ajit Jadhav; Matthew D Hall
Journal:  J Biol Chem       Date:  2018-06-26       Impact factor: 5.157

6.  Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia.

Authors:  Sophie Schweizer; Christoph Harms; Heike Lerch; Jennifer Flynn; Jochen Hecht; Ferah Yildirim; Andreas Meisel; Stefanie Märschenz
Journal:  J Cereb Blood Flow Metab       Date:  2015-05-13       Impact factor: 6.200

7.  P450-Mediated Coupling of Indole Fragments To Forge Communesin and Unnatural Isomers.

Authors:  Hsiao-Ching Lin; Travis C McMahon; Ashay Patel; Michael Corsello; Adam Simon; Wei Xu; Muxun Zhao; K N Houk; Neil K Garg; Yi Tang
Journal:  J Am Chem Soc       Date:  2016-03-18       Impact factor: 15.419

8.  Identification of protoberberine alkaloids as novel histone methyltransferase G9a inhibitors by structure-based virtual screening.

Authors:  Jie Chen; Xiao Lin; Kyoung Jin Park; Kang Ro Lee; Hyun-Ju Park
Journal:  J Comput Aided Mol Des       Date:  2018-08-31       Impact factor: 3.686

Review 9.  A chemical probe toolbox for dissecting the cancer epigenome.

Authors:  Jake Shortt; Christopher J Ott; Ricky W Johnstone; James E Bradner
Journal:  Nat Rev Cancer       Date:  2017-02-23       Impact factor: 60.716

Review 10.  Targeting the histone orthography of cancer: drugs for writers, erasers and readers.

Authors:  Laia Simó-Riudalbas; Manel Esteller
Journal:  Br J Pharmacol       Date:  2014-09-05       Impact factor: 8.739
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