Literature DB >> 23413832

Zic2 is required for enteric nervous system development and neurite outgrowth: a mouse model of enteric hyperplasia and dysplasia.

Y Zhang1, L Niswander.   

Abstract

From a forward genetic screen in mice we isolated a novel Zic2 allele with abnormal aggregation of meconium in the gastrointestinal tract. Zic2(m1Nisw) mutant embryos show an increase in the number of enteric neurons in vivo and disorganization of the neurite network. Explant culture of Zic2(m1Nisw) gastrointestinal tract show extensive neurite outgrowth, suggesting that Zic2 is a negative regulator of nerve fiber growth. These studies demonstrate a previously unknown function of Zic2 and provide a novel animal model of enteric nervous system dysplasia and hyperplasia.
© 2013 John Wiley & Sons Ltd.

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Year:  2013        PMID： 23413832      PMCID： PMC3862053          DOI： 10.1111/nmo.12101

Source DB:  PubMed          Journal:  Neurogastroenterol Motil        ISSN： 1350-1925            Impact factor:   3.598


  8 in total

1.  Zic2 patterns binocular vision by specifying the uncrossed retinal projection.

Authors:  Eloísa Herrera; Lucia Brown; Jun Aruga; Rivka A Rachel; Gül Dolen; Katsuhiko Mikoshiba; Stephen Brown; Carol A Mason
Journal:  Cell       Date:  2003-09-05       Impact factor: 41.582

2.  Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase.

Authors:  Toshifumi Fukuda; Kazutoshi Kiuchi; Masahide Takahashi
Journal:  J Biol Chem       Date:  2002-03-08       Impact factor: 5.157

3.  Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.

Authors:  Mayumi Uchida; Atsushi Enomoto; Toshifumi Fukuda; Kei Kurokawa; Kengo Maeda; Yoshinori Kodama; Naoya Asai; Taisaku Hasegawa; Yohei Shimono; Mayumi Jijiwa; Masatoshi Ichihara; Yoshiki Murakumo; Masahide Takahashi
Journal:  J Cell Sci       Date:  2006-07-04       Impact factor: 5.285

4.  Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase.

Authors:  Maki Ishida; Masatoshi Ichihara; Shinji Mii; Mayumi Jijiwa; Naoya Asai; Atsushi Enomoto; Takuya Kato; Ai Majima; Jiang Ping; Yoshiki Murakumo; Masahide Takahashi
Journal:  Cancer Sci       Date:  2007-03-27       Impact factor: 6.716

Review 5.  Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse.

Authors:  Irene E Zohn; Kathryn V Anderson; Lee Niswander
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2005-09

6.  Clinical and histologic studies of neuronal intestinal dysplasia.

Authors:  K Munakata; K Morita; I Okabe; H Sueoka
Journal:  J Pediatr Surg       Date:  1985-06       Impact factor: 2.545

7.  KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.

Authors:  Ruyun Zhou; Shinsuke Niwa; Noriko Homma; Yosuke Takei; Nobutaka Hirokawa
Journal:  Cell       Date:  2009-11-13       Impact factor: 41.582

Review 8.  Development of enteric neuron diversity.

Authors:  Marlene M Hao; Heather M Young
Journal:  J Cell Mol Med       Date:  2009-06-16       Impact factor: 5.310
  8 in total
  4 in total

Review 1.  Simple rules for a "simple" nervous system? Molecular and biomathematical approaches to enteric nervous system formation and malformation.

Authors:  Donald F Newgreen; Sylvie Dufour; Marthe J Howard; Kerry A Landman
Journal:  Dev Biol       Date:  2013-07-06       Impact factor: 3.582

Review 2.  Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.

Authors:  Nadege Bondurand; E Michelle Southard-Smith
Journal:  Dev Biol       Date:  2016-06-28       Impact factor: 3.582

3.  Why are enteric ganglia so small? Role of differential adhesion of enteric neurons and enteric neural crest cells.

Authors:  Benjamin N Rollo; Dongcheng Zhang; Johanna E Simkin; Trevelyan R Menheniott; Donald F Newgreen
Journal:  F1000Res       Date:  2015-05-12

4.  Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells.

Authors:  Suzy Varderidou-Minasian; Bert M Verheijen; Philipp Schätzle; Casper C Hoogenraad; R Jeroen Pasterkamp; Maarten Altelaar
Journal:  J Proteome Res       Date:  2020-05-15       Impact factor: 4.466
  4 in total

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