| Literature DB >> 19914172 |
Ruyun Zhou1, Shinsuke Niwa, Noriko Homma, Yosuke Takei, Nobutaka Hirokawa.
Abstract
The kinesin superfamily proteins (KIFs) are motor proteins that transport organelles and protein complexes in a microtubule- and ATP-dependent manner. We identified KIF26A as a new member of the murine KIFs. KIF26A is a rather atypical member as it lacks ATPase activity. Mice with a homozygous deletion of Kif26a developed a megacolon with enteric nerve hyperplasia. Kif26a-/- enteric neurons showed hypersensitivity for GDNF-Ret signaling, and we find that KIF26A suppressed GDNF-Ret signaling by direct binding and inhibition of Grb2, an essential component of GDNF/Akt/ERK signaling. We therefore propose that the unconventional kinesin KIF26A plays a key role in enteric nervous system development by repressing a cell growth signaling pathway.Entities:
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Year: 2009 PMID： 19914172 DOI： 10.1016/j.cell.2009.10.023
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582