PURPOSE: To discuss the role of mathematical modeling in studying ocular hemodynamics, with a focus on glaucoma. METHODS: We reviewed recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation. RESULTS: Many studies suggest that alterations in ocular hemodynamics play a significant role in the development, progression, and incidence of glaucoma. Although there is currently a limited number of studies involving mathematical modeling of ocular blood flow, regulation, and diseases (such as glaucoma), preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression. CONCLUSION: Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.
PURPOSE: To discuss the role of mathematical modeling in studying ocular hemodynamics, with a focus on glaucoma. METHODS: We reviewed recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation. RESULTS: Many studies suggest that alterations in ocular hemodynamics play a significant role in the development, progression, and incidence of glaucoma. Although there is currently a limited number of studies involving mathematical modeling of ocular blood flow, regulation, and diseases (such as glaucoma), preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression. CONCLUSION: Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.
Authors: Ian A Sigal; Richard A Bilonick; Larry Kagemann; Gadi Wollstein; Hiroshi Ishikawa; Joel S Schuman; Jonathan L Grimm Journal: Invest Ophthalmol Vis Sci Date: 2012-05-04 Impact factor: 4.799
Authors: Ian A Sigal; Hongli Yang; Michael D Roberts; Claude F Burgoyne; J Crawford Downs Journal: Invest Ophthalmol Vis Sci Date: 2011-03-30 Impact factor: 4.799
Authors: Felipe A Medeiros; Robert N Weinreb; Linda M Zangwill; Luciana M Alencar; Pamela A Sample; Cristiana Vasile; Christopher Bowd Journal: Ophthalmology Date: 2007-10-15 Impact factor: 12.079
Authors: Lin Wang; Grant Cull; Claude F Burgoyne; Simon Thompson; Brad Fortune Journal: Invest Ophthalmol Vis Sci Date: 2014-05-08 Impact factor: 4.799