OBJECTIVE: The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP). METHODS: Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay. RESULTS: The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group. CONCLUSION: The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.
OBJECTIVE: The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP). METHODS: Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay. RESULTS: The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group. CONCLUSION: The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.
Authors: Hannah M Komar; Phil A Hart; Zobeida Cruz-Monserrate; Darwin L Conwell; Gregory B Lesinski Journal: Pancreas Date: 2017-09 Impact factor: 3.327
Authors: Zobeida Cruz-Monserrate; Kristyn Gumpper; Valentina Pita; Phil A Hart; Christopher Forsmark; David C Whitcomb; Dhiraj Yadav; Richard T Waldron; Stephen Pandol; Hanno Steen; Vincent Anani; Natasha Kanwar; Santhi Swaroop Vege; Savi Appana; Liang Li; Jose Serrano; Jo Ann S Rinaudo; Mark Topazian; Darwin L Conwell Journal: Pancreatology Date: 2021-01-22 Impact factor: 3.996
Authors: David S Vitale; Patrick Lahni; Lindsey Hornung; Tyler Thompson; Peter R Farrell; Tom K Lin; Jaimie D Nathan; Hector R Wong; Maisam Abu-El-Haija Journal: PLoS One Date: 2022-02-14 Impact factor: 3.240