[Dynamics of expression of cytokines and lactoferrin in patients with chronic alcohol pancreatitis and chronic relapsing pancreatitis].

The purpose of the research was to estimate the dynamics of production of different cytokines in patients with chronic pancreatitis, depending on the etiologic factor and severity of the disease. Under our supervision there were 112 patients with chronic pancreatitis: 32 patients with alcoholic pancreatitis and 80 patients with chronic relapsing pancreatitis. The dynamics of changes of cytokines parameters was various at chronic pancreatitis, depending on the etiologic factor as well as on the severity of the disease. Our results have allowed revealing significant amplification of production of TNF and have shown that it can be a reliable marker of the severity of aggravation irrespective of the etiologic factor of the disease and can also serve as a prognostic factor.