Literature DB >> 23403429

The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity.

Stephenie Alvarado1, Bracken F Roberts, Amy E Wright, Debopam Chakrabarti.   

Abstract

A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC(50)).

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Year:  2013        PMID： 23403429      PMCID： PMC3632953          DOI： 10.1128/AAC.02091-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

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  8 in total

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