Literature DB >> 17306531

Synthesis and antitumor properties of 2,5-bis(3'-indolyl)thiophenes: analogues of marine alkaloid nortopsentin.

Patrizia Diana1, Anna Carbone, Paola Barraja, Alessandra Montalbano, Annamaria Martorana, Gaetano Dattolo, Ornella Gia, Lisa Dalla Via, Girolamo Cirrincione.   

Abstract

A series of 11 bis-indolylthiophenes of type 8-10 were obtained by cyclization of diketones 4 and 7 using Lawesson's reagent. Derivatives 8c, 9c, 9d, and 10c were selected to be evaluated in the full panel of about 60 human tumor cell lines derived from nine human cancer cell types and showed antiproliferative activity generally in the micromolar range. The most sensitive cell lines were: CCRF-CEM, MOLT-4, HL60 (TB), and RPMI-8226 of the leukemia subpanel, HT29 and HCC-2998 cell lines of the colon sub-panel, NCI-H522 of the non-small cell lung cancer sub-panel, LOX IMVI of the melanoma sub-panel, and UO-31 of the renal cancer sub-panel.

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Year:  2007        PMID： 17306531     DOI： 10.1016/j.bmcl.2007.01.065

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Functionalized ionic liquid-assisted chromatography-free synthesis of bis(indolyl)methanes.

Authors:  Sunita Choudhary; Khima Pandey; Saroj Budania; Anil Kumar
Journal:  Mol Divers       Date:  2017-01-11       Impact factor: 2.943

2.  The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity.

Authors:  Stephenie Alvarado; Bracken F Roberts; Amy E Wright; Debopam Chakrabarti
Journal:  Antimicrob Agents Chemother       Date:  2013-02-12       Impact factor: 5.191

3.  Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues.

Authors:  Anna Carbone; Barbara Parrino; Gloria Di Vita; Alessandro Attanzio; Virginia Spanò; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Maria Antonia Livrea; Patrizia Diana; Girolamo Cirrincione
Journal:  Mar Drugs       Date:  2015-01-16       Impact factor: 5.118

4.  3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity.

Authors:  Barbara Parrino; Anna Carbone; Gloria Di Vita; Cristina Ciancimino; Alessandro Attanzio; Virginia Spanò; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Maria Antonia Livrea; Patrizia Diana; Girolamo Cirrincione
Journal:  Mar Drugs       Date:  2015-04-03       Impact factor: 5.118

5.  Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs.

Authors:  Virginia Spanò; Alessandro Attanzio; Stella Cascioferro; Anna Carbone; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Girolamo Cirrincione; Patrizia Diana; Barbara Parrino
Journal:  Mar Drugs       Date:  2016-12-14       Impact factor: 5.118

6.  Synthesis and anticancer activity of di(3-thienyl)methanol and di(3-thienyl)methane.

Authors:  Nagendra Kumar Kaushik; Hong Seon Kim; Young June Chae; Young Nam Lee; Gi-Chung Kwon; Eun Ha Choi; In Tae Kim
Journal:  Molecules       Date:  2012-09-27       Impact factor: 4.411

7.  Microwave assisted synthesis of bis and tris(ω-bromoacetophenones): versatile precursors for novel bis(imidazo[1,2-a]pyridines), bis(imidazo[1,2-a]pyrimidines) and their tris-analogs.

Authors:  Mohamed R Shaaban
Journal:  Chem Cent J       Date:  2013-06-19       Impact factor: 4.215

8.  Synthesis and antiproliferative activity of 2,5-bis(3'-indolyl)pyrroles, analogues of the marine alkaloid nortopsentin.

Authors:  Anna Carbone; Barbara Parrino; Paola Barraja; Virginia Spanò; Girolamo Cirrincione; Patrizia Diana; Armin Maier; Gerhard Kelter; Heinz-Herbert Fiebig
Journal:  Mar Drugs       Date:  2013-03-01       Impact factor: 5.118

9.  Synthesis and antimicrobial evaluation of some novel bis-α,β-unsaturated ketones, nicotinonitrile, 1,2-dihydropyridine-3-carbonitrile, fused thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives.

Authors:  Farag M A Altalbawy
Journal:  Int J Mol Sci       Date:  2013-01-30       Impact factor: 5.923

10.  One-pot synthesis and in-vitro anticancer evaluation of 5-(2'-indolyl)thiazoles.

Authors:  Buchi Reddy Vaddula; Mukund P Tantak; Rachana Sadana; Michael A Gonzalez; Dalip Kumar
Journal:  Sci Rep       Date:  2016-03-29       Impact factor: 4.379
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