Literature DB >> 23402174

[Antiproliferative activity of diclofenac at tumor cell cultures].

A V Smirnova, L B Lazebnik, I E Trubitsina, E V Tkachenko, G G Varvarina, V N Drozdov, V A Kim, A Iu Baryshnikova, Z A Sokolova.   

Abstract

It is known that for risk group's importance of early diagnostics and prevention of a cancer of a thick section of the intestines. The view was expressed that the use of nonsteroidal anti-inflammatory drugs prospectively. The article presents the data obtained after the determination of the effect on the domestic drug diclofenac on the ability of the lines of tumor cells of the human colon multiply this antiproliferativoe action on the dose of the drug. Used photometric method for determination antiproliferativoe action. In vitro determined the effect of the national drug diclofenac on the ability of the lines of tumor cells of the human colon multiply, and is set in a dose-dependent effect. It is established that under the action of NSAIDS metabolic activity of cells can both strengthen and weaken that depends on the line of tumor cells and the concentration of the drug.

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Year:  2012        PMID: 23402174

Source DB:  PubMed          Journal:  Eksp Klin Gastroenterol        ISSN: 1682-8658


  3 in total

1.  Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma.

Authors:  Silvia Tampucci; Sara Carpi; Maria Digiacomo; Beatrice Polini; Stefano Fogli; Susi Burgalassi; Marco Macchia; Paola Nieri; Clementina Manera; Daniela Monti
Journal:  Molecules       Date:  2019-05-09       Impact factor: 4.411

2.  Promising Hybrids Derived from S-Allylcysteine and NSAIDs Fragments against Colorectal Cancer: Synthesis, In-vitro Evaluation, Drug-Likeness and In-silico ADME/tox Studies.

Authors:  Angie Herrera-R; Wilson Castrillón; Manuel Pastrana; Andres F Yepes; Wilson Cardona-G
Journal:  Iran J Pharm Res       Date:  2021       Impact factor: 1.696

3.  Antiproliferative effects of aspirin and diclofenac against the growth of cancer and fibroblast cells: In vitro comparative study.

Authors:  Marwan S M Al-Nimer; Huda G Hameed; Majid M Mahmood
Journal:  Saudi Pharm J       Date:  2015-01-10       Impact factor: 4.330

  3 in total

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