Long-term reproducibility of cirrus HD optical coherence tomography deviation map in clinically stable glaucomatous eyes.

OBJECTIVE: To determine the long-term reproducibility of the retinal nerve fiber layer (RNFL) thickness deviation map in glaucoma patients.
DESIGN: Retrospective, longitudinal study. PARTICIPANTS: One hundred two eyes of 102 glaucoma patients.
METHODS: From a total of 318 screened glaucoma patients who had undergone at least 3 serial Cirrus HD optical coherence tomography sessions during an 18-month or longer follow-up period, 102 eyes with localized RNFL defects on red-free photographs that did not progress during this period based on stereoscopic disc photography, red-free photography, and standard automated perimetry (SAP) were included. The angular widths from the RNFL thickness deviation maps and average, clock-hour, and quadrant-map thicknesses of the RNFL defects were measured serially to assess intersession variability. MAIN OUTCOME MEASURES: Intraclass correlation coefficient (ICC), coefficient of variation (CV), test-retest standard deviation (TRT SD), and tolerance limit.
RESULTS: The ICC, CV, and TRT SD were 0.994, 4.2%, and 1.46°, respectively, for the angular widths; 0.944, 3.1%, and 2.35 μm, respectively, for the average thicknesses; and 0.840 and 0.934, 7.8% and 6.4%, and 7.21 and 5.58 μm, respectively, for the superior and inferior quadrant positions of the RNFL defects. The severity of glaucoma based on the mean deviation of SAP did not affect the reproducibility of the angular widths (TRT SD, 1.3° and 1.84°, respectively; P = 0.905).
CONCLUSIONS: Both the angular widths of RNFL defects in the RNFL thickness deviation map and conventional peripapillary thickness parameters exhibit excellent long-term reproducibility. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.