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Literature DB >> 23395658

Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.

Yoko Beniyama¹, Kenji Matsuno, Hiroyuki Miyachi.

Abstract

We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4)-selective inhibitor (BMS309403) complex and FABP3-elaidic acid complex. Some of the synthesized compounds exhibited dual FABP3/4 ligand activity, and some exhibited selectivity for FABP3.

Entities: Chemical Gene

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Year: 2013 PMID： 23395658 DOI： 10.1016/j.bmcl.2013.01.054

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

1. Single-nucleotide polymorphisms in FABP4 gene associated with growth traits in Egyptian sheep.

Authors: Heba Ibrahim Shafey; Karima Fathy Mahrous; Amal Ahmed Mohamed Hassan; Hossam Eldin Rushdi; Mohamed Abd El-Aziz Mohamed Ibrahim
Journal: Vet World Date: 2020-06-17

2. Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress.

Authors: An Cheng; Yi-Fei Wang; Yasuharu Shinoda; Ichiro Kawahata; Tetsunori Yamamoto; Wen-Bin Jia; Hanae Yamamoto; Tomohiro Mizobata; Yasushi Kawata; Kohji Fukunaga
Journal: Acta Pharmacol Sin Date: 2021-05-02 Impact factor: 6.150

3. Association of H-FABP gene polymorphisms with intramuscular fat content in Three-yellow chickens and Hetian-black chickens.

Authors: Yong Wang; Xiaohong Hui; Huie Wang; Tursunjan Kurban; Chao Hang; Ying Chen; Jinming Xing; Jiufeng Wang
Journal: J Anim Sci Biotechnol Date: 2016-02-18

Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.

1. Single-nucleotide polymorphisms in FABP4 gene associated with growth traits in Egyptian sheep.

2. Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress.

3. Association of H-FABP gene polymorphisms with intramuscular fat content in Three-yellow chickens and Hetian-black chickens.

4. Fatty Acid-Binding Proteins Aggravate Cerebral Ischemia-Reperfusion Injury in Mice.

5. Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA_A Receptor.

6. Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain.

7. Stomach secretes estrogen in response to the blood triglyceride levels.