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Literature DB >> 23395443

Mechanisms that regulate stem cell aging and life span.

Abstract

Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.

Entities: Chemical

Mesh：

Year: 2013 PMID： 23395443 PMCID： PMC3641677 DOI： 10.1016/j.stem.2013.01.001

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

196 in total

1. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.

Authors: Coleen T Murphy; Steven A McCarroll; Cornelia I Bargmann; Andrew Fraser; Ravi S Kamath; Julie Ahringer; Hao Li; Cynthia Kenyon
Journal: Nature Date: 2003-06-29 Impact factor: 49.962

Review 2. mTOR signaling in growth control and disease.

Authors: Mathieu Laplante; David M Sabatini
Journal: Cell Date: 2012-04-13 Impact factor: 41.582

3. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.

Authors: Seung Wook Oh; Arnab Mukhopadhyay; Bharat L Dixit; Tamal Raha; Michael R Green; Heidi A Tissenbaum
Journal: Nat Genet Date: 2005-12-25 Impact factor: 38.330

Review 4. Molecular chaperones in protein folding and proteostasis.

Authors: F Ulrich Hartl; Andreas Bracher; Manajit Hayer-Hartl
Journal: Nature Date: 2011-07-20 Impact factor: 49.962

5. Genetic differences in effects of food restriction on aging in mice.

Authors: D E Harrison; J R Archer
Journal: J Nutr Date: 1987-02 Impact factor: 4.798

6. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.

Authors: Fabio Demontis; Norbert Perrimon
Journal: Cell Date: 2010-11-24 Impact factor: 41.582

7. Caloric restriction delays disease onset and mortality in rhesus monkeys.

Authors: Ricki J Colman; Rozalyn M Anderson; Sterling C Johnson; Erik K Kastman; Kristopher J Kosmatka; T Mark Beasley; David B Allison; Christina Cruzen; Heather A Simmons; Joseph W Kemnitz; Richard Weindruch
Journal: Science Date: 2009-07-10 Impact factor: 47.728

8. Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest.

Authors: Keiyo Takubo; Masako Ohmura; Masaki Azuma; Go Nagamatsu; Wakako Yamada; Fumio Arai; Atsushi Hirao; Toshio Suda
Journal: Cell Stem Cell Date: 2008-02-07 Impact factor: 24.633

9. Delayed ageing through damage protection by the Arf/p53 pathway.

Authors: Ander Matheu; Antonio Maraver; Peter Klatt; Ignacio Flores; Isabel Garcia-Cao; Consuelo Borras; Juana M Flores; Jose Viña; Maria A Blasco; Manuel Serrano
Journal: Nature Date: 2007-07-19 Impact factor: 49.962

10. O2 regulates stem cells through Wnt/β-catenin signalling.

Authors: Jolly Mazumdar; W Timothy O'Brien; Randall S Johnson; Joseph C LaManna; Juan C Chavez; Peter S Klein; M Celeste Simon
Journal: Nat Cell Biol Date: 2010-09-19 Impact factor: 28.824

145 in total

Review 1. Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine.

Authors: L Lum; C Chen
Journal: Curr Med Chem Date: 2015 Impact factor: 4.530

Review 2. mTOR signaling in stem and progenitor cells.

Authors: Delong Meng; Anderson R Frank; Jenna L Jewell
Journal: Development Date: 2018-01-08 Impact factor: 6.868

Review 3. Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.

Authors: Robert L Bowman; Lambert Busque; Ross L Levine
Journal: Cell Stem Cell Date: 2018-02-01 Impact factor: 24.633

Review 4. DNA damage and tissue repair: What we can learn from planaria.

Authors: Paul G Barghouth; Manish Thiruvalluvan; Melanie LeGro; Néstor J Oviedo
Journal: Semin Cell Dev Biol Date: 2018-05-03 Impact factor: 7.727

5. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.

Authors: Maria M Mihaylova; Chia-Wei Cheng; Amanda Q Cao; Surya Tripathi; Miyeko D Mana; Khristian E Bauer-Rowe; Monther Abu-Remaileh; Laura Clavain; Aysegul Erdemir; Caroline A Lewis; Elizaveta Freinkman; Audrey S Dickey; Albert R La Spada; Yanmei Huang; George W Bell; Vikram Deshpande; Peter Carmeliet; Pekka Katajisto; David M Sabatini; Ömer H Yilmaz
Journal: Cell Stem Cell Date: 2018-05-03 Impact factor: 24.633