OBJECTIVE: Schizotypal features indicate proneness to psychosis in the general population. It is also possible that they increase transition to psychosis (TTP) among clinical high-risk patients (CHR). Our aim was to investigate whether schizotypal features predict TTP in CHR patients. METHODS: In the EPOS (European Prediction of Psychosis Study) project, 245 young help-seeking CHR patients were prospectively followed for 18 months and their TTP was identified. At baseline, subjects were assessed with the Schizotypal Personality Questionnaire (SPQ). Associations between SPQ items and its subscales with the TTP were analysed in Cox regression analysis. RESULTS: The SPQ subscales and items describing ideas of reference and lack of close interpersonal relationships were found to correlate significantly with TTP. The co-occurrence of these features doubled the risk of TTP. CONCLUSIONS: Presence of ideas of reference and lack of close interpersonal relations increase the risk of full-blown psychosis among CHR patients. This co-occurrence makes the risk of psychosis very high.
OBJECTIVE: Schizotypal features indicate proneness to psychosis in the general population. It is also possible that they increase transition to psychosis (TTP) among clinical high-risk patients (CHR). Our aim was to investigate whether schizotypal features predict TTP in CHRpatients. METHODS: In the EPOS (European Prediction of Psychosis Study) project, 245 young help-seeking CHRpatients were prospectively followed for 18 months and their TTP was identified. At baseline, subjects were assessed with the Schizotypal Personality Questionnaire (SPQ). Associations between SPQ items and its subscales with the TTP were analysed in Cox regression analysis. RESULTS: The SPQ subscales and items describing ideas of reference and lack of close interpersonal relationships were found to correlate significantly with TTP. The co-occurrence of these features doubled the risk of TTP. CONCLUSIONS: Presence of ideas of reference and lack of close interpersonal relations increase the risk of full-blown psychosis among CHRpatients. This co-occurrence makes the risk of psychosis very high.
Authors: Charity J Morgan; Michael J Coleman; Ayse Ulgen; Lenore Boling; Jonathan O Cole; Frederick V Johnson; Jan Lerbinger; J Alexander Bodkin; Philip S Holzman; Deborah L Levy Journal: Schizophr Bull Date: 2017-05-01 Impact factor: 9.306
Authors: Eduardo Fonseca-Pedrero; Javier Ortuño; Martin Debbané; Raymond C K Chan; David Cicero; Lisa C Zhang; Colleen Brenner; Emma Barkus; Richard J Linscott; Thomas Kwapil; Neus Barrantes-Vidal; Alex Cohen; Adrian Raine; Michael T Compton; Erin B Tone; Julie Suhr; Felix Inchausti; Julio Bobes; Axit Fumero; Stella Giakoumaki; Ioannis Tsaousis; Antonio Preti; Michael Chmielewski; Julien Laloyaux; Anwar Mechri; Mohamed Aymen Lahmar; Viviana Wuthrich; Frank Larøi; Johanna C Badcock; Assen Jablensky; Adela M Isvoranu; Sacha Epskamp; Eiko I Fried Journal: Schizophr Bull Date: 2018-10-15 Impact factor: 9.306
Authors: Diana O Perkins; Clark D Jeffries; Barbara A Cornblatt; Scott W Woods; Jean Addington; Carrie E Bearden; Kristin S Cadenhead; Tyrone D Cannon; Robert Heinssen; Daniel H Mathalon; Larry J Seidman; Ming T Tsuang; Elaine F Walker; Thomas H McGlashan Journal: Schizophr Res Date: 2015-10-04 Impact factor: 4.939