BACKGROUND: Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults. METHODS: Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1 rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system. RESULTS: The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women. LIMITATIONS: A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument. CONCLUSIONS: The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology.
BACKGROUND: Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults. METHODS:Participants included 326 victims who experienced 2008 Wenchuan earthquake and lost their children during the disaster. PTSD symptoms were assessed with the PTSD Checklist (PCL). The ADCYAP1R1rs2267735 SNP was genotyped with the Sequenom iPlex chemistries and the MassARRAY system. RESULTS: The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women. LIMITATIONS: A relatively small sample exposed to specific traumatic events was used, and PTSD was assessed using a self-reported instrument. CONCLUSIONS: The findings suggest that the PACAP-PAC1 receptor pathway may play an important role in female human responses to traumatic stress, and carry implications for better understanding and treating of posttraumatic psychopathology.
Authors: K R Lezak; E Roelke; O M Harris; I Choi; S Edwards; N Gick; G Cocchiaro; G Missig; C W Roman; K M Braas; D J Toufexis; V May; S E Hammack Journal: Psychoneuroendocrinology Date: 2014-03-25 Impact factor: 4.905
Authors: Barbara O Rothbaum; Megan C Kearns; Emily Reiser; Jennifer S Davis; Kimberly A Kerley; Alex O Rothbaum; Kristina B Mercer; Matthew Price; Debra Houry; Kerry J Ressler Journal: J Clin Psychiatry Date: 2014-12 Impact factor: 4.384
Authors: Vasiliki Michopoulos; Alex O Rothbaum; Tanja Jovanovic; Lynn M Almli; Bekh Bradley; Barbara O Rothbaum; Charles F Gillespie; Kerry J Ressler Journal: Am J Psychiatry Date: 2014-12-12 Impact factor: 18.112
Authors: John M Brehm; Sima K Ramratnam; Sze Man Tse; Damien C Croteau-Chonka; Maria Pino-Yanes; Christian Rosas-Salazar; Augusto A Litonjua; Benjamin A Raby; Nadia Boutaoui; Yueh-Ying Han; Wei Chen; Erick Forno; Anna L Marsland; Nicole R Nugent; Celeste Eng; Angel Colón-Semidey; María Alvarez; Edna Acosta-Pérez; Melissa L Spear; Fernando D Martinez; Lydiana Avila; Scott T Weiss; Manuel Soto-Quiros; Carole Ober; Dan L Nicolae; Kathleen C Barnes; Robert F Lemanske; Robert C Strunk; Andrew Liu; Stephanie J London; Frank Gilliland; Patrick Sleiman; Michael March; Hakon Hakonarson; Qing Ling Duan; Jay K Kolls; Gregory K Fritz; Donglei Hu; Negar Fani; Jennifer S Stevens; Lynn M Almli; Esteban G Burchard; Jaemin Shin; Elizabeth L McQuaid; Kerry Ressler; Glorisa Canino; Juan C Celedón Journal: Am J Respir Crit Care Med Date: 2015-07-01 Impact factor: 21.405
Authors: Galen Missig; Carolyn W Roman; Margaret A Vizzard; Karen M Braas; Sayamwong E Hammack; Victor May Journal: Neuropharmacology Date: 2014-07-03 Impact factor: 5.250