Literature DB >> 30452941

Genomic updates in understanding PTSD.

Sumeet Sharma1, Kerry J Ressler2.   

Abstract

Twin studies as well as more recent genetics-based heritability analyses demonstrate that up to 40 to 50% of the variance in predicting PTSD following trauma is heritable. However, most of the specific gene pathways and mechanism that mediate risk vs. resilience for PTSD following trauma exposure have yet to be elucidated. This review will examine the latest results from large scale Genome-wide association studies as well as other approaches aimed at understanding mechanisms of development of and recovery from PTSD.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anxiety; Depression; Epigenetic; Gene-by-environment interaction; PTSD; Stress; Trauma

Mesh：

Year:  2018        PMID： 30452941      PMCID： PMC6431237          DOI： 10.1016/j.pnpbp.2018.11.010

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN： 0278-5846            Impact factor:   5.067


  76 in total

1.  Effects of early adverse experiences on brain structure and function: clinical implications.

Authors:  J Kaufman; P M Plotsky; C B Nemeroff; D S Charney
Journal:  Biol Psychiatry       Date:  2000-10-15       Impact factor: 13.382

2.  Obstetric complications and schizophrenia: historical and meta-analytic review.

Authors:  Mary Cannon; Peter B Jones; Robin M Murray
Journal:  Am J Psychiatry       Date:  2002-07       Impact factor: 18.112

3.  The psychological risks of Vietnam for U.S. veterans: a revisit with new data and methods.

Authors:  Bruce P Dohrenwend; J Blake Turner; Nicholas A Turse; Ben G Adams; Karestan C Koenen; Randall Marshall
Journal:  Science       Date:  2006-08-18       Impact factor: 47.728

Review 4.  The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies.

Authors:  C Heim; C B Nemeroff
Journal:  Biol Psychiatry       Date:  2001-06-15       Impact factor: 13.382

5.  Unresolved attachment, PTSD, and dissociation in women with childhood abuse histories.

Authors:  K Chase Stovall-McClough; Marylene Cloitre
Journal:  J Consult Clin Psychol       Date:  2006-04

6.  Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenia and other nonaffective psychoses: a 19-year longitudinal study.

Authors:  G L Zornberg; S L Buka; M T Tsuang
Journal:  Am J Psychiatry       Date:  2000-02       Impact factor: 18.112

Review 7.  Neurobiology of early life stress: clinical studies.

Authors:  Christine Heim; Charles B Nemeroff
Journal:  Semin Clin Neuropsychiatry       Date:  2002-04

8.  Vulnerability to assaultive violence: further specification of the sex difference in post-traumatic stress disorder.

Authors:  N Breslau; H D Chilcoat; R C Kessler; E L Peterson; V C Lucia
Journal:  Psychol Med       Date:  1999-07       Impact factor: 7.723

9.  Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.

Authors:  Elisabeth B Binder; Daria Salyakina; Peter Lichtner; Gabriele M Wochnik; Marcus Ising; Benno Pütz; Sergi Papiol; Shaun Seaman; Susanne Lucae; Martin A Kohli; Thomas Nickel; Heike E Künzel; Brigitte Fuchs; Matthias Majer; Andrea Pfennig; Nikola Kern; Jürgen Brunner; Sieglinde Modell; Thomas Baghai; Tobias Deiml; Peter Zill; Brigitta Bondy; Rainer Rupprecht; Thomas Messer; Oliver Köhnlein; Heike Dabitz; Tanja Brückl; Nina Müller; Hildegard Pfister; Roselind Lieb; Jakob C Mueller; Elin Lõhmussaar; Tim M Strom; Thomas Bettecken; Thomas Meitinger; Manfred Uhr; Theo Rein; Florian Holsboer; Bertram Muller-Myhsok
Journal:  Nat Genet       Date:  2004-11-21       Impact factor: 38.330

10.  Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study.

Authors:  Murray B Stein; Kerry L Jang; Steven Taylor; Philip A Vernon; W John Livesley
Journal:  Am J Psychiatry       Date:  2002-10       Impact factor: 18.112
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  12 in total

1.  FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors.

Authors:  Gen Li; Li Wang; Kunlin Zhang; Chengqi Cao; Xing Cao; Ruojiao Fang; Ping Liu; Shu Luo; Xiangyang Zhang
Journal:  Can J Psychiatry       Date:  2019-09-11       Impact factor: 4.356

2.  The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli.

Authors:  Daniel Porta-Casteràs; Marta Cano; Trevor Steward; Raül Andero; Narcís Cardoner
Journal:  Neurobiol Stress       Date:  2022-04-14

3.  Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex.

Authors:  Tanja Jovanovic; Anaïs F Stenson; Nadia Thompson; Aimee Clifford; Alisha Compton; Sean Minton; Sanne J F van Rooij; Jennifer S Stevens; Adriana Lori; Nicole Nugent; Charles F Gillespie; Bekh Bradley; Kerry J Ressler
Journal:  Neuropsychopharmacology       Date:  2020-06-26       Impact factor: 7.853

4.  Gene-Environment Interactions in Major Mental Disorders in the Czech Republic.

Authors:  Klara Latalova; Omar Sery; Kristyna Hosakova; Ladislav Hosak
Journal:  Neuropsychiatr Dis Treat       Date:  2020-05-06       Impact factor: 2.570

5.  Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs.

Authors:  H Le-Niculescu; K Roseberry; D F Levey; J Rogers; K Kosary; S Prabha; T Jones; S Judd; M A McCormick; A R Wessel; A Williams; P L Phalen; F Mamdani; A Sequeira; S M Kurian; A B Niculescu
Journal:  Mol Psychiatry       Date:  2019-03-12       Impact factor: 15.992

6.  Social support modulates the association between PTSD diagnosis and medial frontal volume in Chinese adults who lost their only child.

Authors:  Rongfeng Qi; Yifeng Luo; Li Zhang; Yifei Weng; Wesley Surento; Neda Jahanshad; Qiang Xu; Yan Yin; Lingjiang Li; Zhihong Cao; Paul M Thompson; Guang Ming Lu
Journal:  Neurobiol Stress       Date:  2020-05-11

7.  Polygenic risk scoring to assess genetic overlap and protective factors influencing posttraumatic stress, depression, and chronic pain after motor vehicle collision trauma.

Authors:  Jarred J Lobo; Samuel A McLean; Andrew S Tungate; David A Peak; Robert A Swor; Niels K Rathlev; Phyllis L Hendry; Sarah D Linnstaedt
Journal:  Transl Psychiatry       Date:  2021-06-29       Impact factor: 6.222

8.  Neurological disorder-associated genetic variants in individuals with psychogenic nonepileptic seizures.

Authors:  Costin Leu; Jocelyn F Bautista; Monica Sudarsanam; Lisa-Marie Niestroj; Arthur Stefanski; Lisa Ferguson; Mark J Daly; Lara Jehi; Imad M Najm; Robyn M Busch; Dennis Lal
Journal:  Sci Rep       Date:  2020-09-16       Impact factor: 4.379

Review 9.  Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure.

Authors:  Sarah D Linnstaedt; Anthony S Zannas; Samuel A McLean; Karestan C Koenen; Kerry J Ressler
Journal:  Mol Psychiatry       Date:  2019-12-20       Impact factor: 15.992

10.  Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child.

Authors:  Rongfeng Qi; Yifeng Luo; Li Zhang; Yifei Weng; Wesley Surento; Lingjiang Li; Zhihong Cao; Guang Ming Lu
Journal:  Transl Psychiatry       Date:  2020-01-30       Impact factor: 6.222
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