| Literature DB >> 23394120 |
Gavin Chit Tsui1, Nina M Ninnemann, Akihito Hosotani, Mark Lautens.
Abstract
A method for synthesizing chiral oxazolidinone scaffolds from readily available oxabicyclic alkenes is described. The reaction utilizes a domino sequence of Rh(I)-catalyzed asymmetric ring-opening (ARO) with sodium cyanate as a novel nucleophile followed by intramolecular cyclization to generate oxazolidinone products in excellent enantioselectivities (trans stereochemistry).Entities:
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Year: 2013 PMID： 23394120 DOI： 10.1021/ol4000668
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005