AIM: The value of grading tumor regression after neoadjuvant therapy of rectal carcinoma was evaluated. PATIENTS AND METHODS: Analysis was carried out using prospective data of 225 patients with rectal carcinoma treated by neoadjuvant radiochemotherapy followed by radical resection with curative intent. For the histological regression grading, the method of Dworak et al. (1997) was used with a slight modification. RESULTS: After neoadjuvant radiochemotherapy, the most important prognostic factors are pathologically assessed circumferential resection margin, quality of surgery (plane of surgery), and the ypT and ypN classification. In addition, the histological regression grade of primary tumor and regional lymph nodes influence outcome, especially the local recurrence rate. CONCLUSION: After neoadjuvant therapy, the histological tumor regression grading should be assessed. A regression grading system based on the proposals of Dworak et al. (1997) is recommended.
AIM: The value of grading tumor regression after neoadjuvant therapy of rectal carcinoma was evaluated. PATIENTS AND METHODS: Analysis was carried out using prospective data of 225 patients with rectal carcinoma treated by neoadjuvant radiochemotherapy followed by radical resection with curative intent. For the histological regression grading, the method of Dworak et al. (1997) was used with a slight modification. RESULTS: After neoadjuvant radiochemotherapy, the most important prognostic factors are pathologically assessed circumferential resection margin, quality of surgery (plane of surgery), and the ypT and ypN classification. In addition, the histological regression grade of primary tumor and regional lymph nodes influence outcome, especially the local recurrence rate. CONCLUSION: After neoadjuvant therapy, the histological tumor regression grading should be assessed. A regression grading system based on the proposals of Dworak et al. (1997) is recommended.
Authors: Marcus Kiehlmann; Klaus Weber; Jonas Göhl; Rainer Fietkau; Abbas Agaimy; Werner Hohenberger; Susanne Merkel Journal: Int J Colorectal Dis Date: 2015-10-24 Impact factor: 2.571
Authors: Soo Hee Kim; Hee Jin Chang; Dae Yong Kim; Ji Won Park; Ji Yeon Baek; Sun Young Kim; Sung Chan Park; Jae Hwan Oh; Ami Yu; Byung-Ho Nam Journal: Cancer Res Treat Date: 2015-10-22 Impact factor: 4.679
Authors: Muhammed R S Siddiqui; Jemma Bhoday; Nicholas J Battersby; Manish Chand; Nicholas P West; Al-Mutaz Abulafi; Paris P Tekkis; Gina Brown Journal: World J Gastroenterol Date: 2016-10-07 Impact factor: 5.742
Authors: Roland S Croner; Müzeyyen Sevim; Metodi V Metodiev; Peter Jo; Michael Ghadimi; Vera Schellerer; Maximillian Brunner; Carol Geppert; Tilman Rau; Michael Stürzl; Elisabeth Naschberger; Klaus E Matzel; Werner Hohenberger; Friedrich Lottspeich; Josef Kellermann Journal: Int J Mol Sci Date: 2016-02-04 Impact factor: 5.923