PURPOSE: Both hepatic steatosis (HS) and colorectal cancer (CRC) are conditions associated with metabolic syndrome. The liver is the most frequent site of distant metastasis of CRC; however, the impact of HS on the incidence of liver metastasis of CRC is not clearly defined. Then, the correlation with the presence or absence of HS was analyzed. METHODS: A total of 604 CRC patients receiving curative surgical resection who had a preoperative non-enhanced computed tomography (CT) were enrolled. The mean attenuation values (in Hounsfield units) of the liver and spleen were obtained on a plain CT slice, and the patients with liver-spleen attenuation ratio lower than 1.1 were objectively defined as HS. The clinicopathological features of these patients were analyzed, and the association between HS and the clinical features of CRC was examined. RESULTS: Sixty-three (10.4%) among the 604 patients were diagnosed as HS. Recurrence-free survival (RFS) and hepatic RFS, but not extrahepatic RFS, were significantly higher in the group with HS (p = 0.04 and p = 0.006). However, this effect was not evident in the group of patients with obesity, defined as body mass index > 25.0. Among the stage I~III cases, HS was significantly associated with lower hepatic, but not extrahepatic, RFS. Moreover, absence of HS was an independent risk factor for hepatic RFS (p = 0.003). CONCLUSION: Metastases of CRC are less frequent in fatty liver. Steatosis may be an unfavorable microenvironment for metastatic formation in the liver.
PURPOSE: Both hepatic steatosis (HS) and colorectal cancer (CRC) are conditions associated with metabolic syndrome. The liver is the most frequent site of distant metastasis of CRC; however, the impact of HS on the incidence of liver metastasis of CRC is not clearly defined. Then, the correlation with the presence or absence of HS was analyzed. METHODS: A total of 604 CRC patients receiving curative surgical resection who had a preoperative non-enhanced computed tomography (CT) were enrolled. The mean attenuation values (in Hounsfield units) of the liver and spleen were obtained on a plain CT slice, and the patients with liver-spleen attenuation ratio lower than 1.1 were objectively defined as HS. The clinicopathological features of these patients were analyzed, and the association between HS and the clinical features of CRC was examined. RESULTS: Sixty-three (10.4%) among the 604 patients were diagnosed as HS. Recurrence-free survival (RFS) and hepatic RFS, but not extrahepatic RFS, were significantly higher in the group with HS (p = 0.04 and p = 0.006). However, this effect was not evident in the group of patients with obesity, defined as body mass index > 25.0. Among the stage I~III cases, HS was significantly associated with lower hepatic, but not extrahepatic, RFS. Moreover, absence of HS was an independent risk factor for hepatic RFS (p = 0.003). CONCLUSION:Metastases of CRC are less frequent in fatty liver. Steatosis may be an unfavorable microenvironment for metastatic formation in the liver.
Authors: Seung Soo Lee; Seong Ho Park; Hye Jin Kim; So Yeon Kim; Min-Yeong Kim; Dae Yoon Kim; Dong Jin Suh; Kang Mo Kim; Mi Hyun Bae; Joo Yeon Lee; Sung-Gyu Lee; Eun Sil Yu Journal: J Hepatol Date: 2010-02-02 Impact factor: 25.083
Authors: T Kawano; T Nakayama; N Kamada; Y Kaneko; M Harada; N Ogura; Y Akutsu; S Motohashi; T Iizasa; H Endo; T Fujisawa; H Shinkai; M Taniguchi Journal: Cancer Res Date: 1999-10-15 Impact factor: 12.701
Authors: Raja R Narayan; Jennifer W Harris; Joanne F Chou; Mithat Gönen; Fei Bao; Jinru Shia; Peter J Allen; Vinod P Balachandran; Jeffrey A Drebin; William R Jarnagin; Nancy E Kemeny; T Peter Kingham; Michael I D'Angelica Journal: Ann Surg Oncol Date: 2019-10-15 Impact factor: 5.344
Authors: Kana Wu; Mike Z Zhai; Erin K Weltzien; Elizabeth M Cespedes Feliciano; Jeffrey A Meyerhardt; Edward Giovannucci; Bette J Caan Journal: Cancer Causes Control Date: 2018-11-15 Impact factor: 2.506
Authors: N W Molla; M M Hassanain; Z Fadel; L M Boucher; A Madkhali; R M Altahan; E A Alrijraji; E B Simoneau; H Alamri; A Salman; Z Gao; P P Metrakos Journal: Curr Oncol Date: 2017-06-27 Impact factor: 3.677
Authors: Piotr Spychalski; Jarek Kobiela; Paulina Wieszczy; Michał F Kamiński; Jarosław Reguła Journal: United European Gastroenterol J Date: 2019-03-21 Impact factor: 4.623