Alban Zarzavadjian Le Bian1,2, Christine Denet3, Nicolas Tabchouri3, Gianfranco Donatelli4, Philippe Wind5, Christophe Louvet6, Mostefa Bennamoun6, Christos Christidis3, Thierry Perniceni3, David Fuks3,7, Brice Gayet3,7. 1. Department of Digestive Surgery, CHU Avicenne, Assistante Publique - Hôpitaux de Paris, Université Paris XIII, 125, rue de Stalingrad, 93000, Bobigny, France. spleen2008@live.fr. 2. Laboratory of Medical Ethics and Legal Medicine, University Paris Descartes, 45, rue des Saint-Pères, 75006, Paris, France. spleen2008@live.fr. 3. Department of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France. 4. Department of Digestive Endoscopy, Hôpital Privé de la Poterne des Peupliers, 8 place de l'Abbé Hénocque, 75013, Paris, France. 5. Department of Digestive Surgery, CHU Avicenne, Assistante Publique - Hôpitaux de Paris, Université Paris XIII, 125, rue de Stalingrad, 93000, Bobigny, France. 6. Department of Oncology, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France. 7. Université Paris Descartes, 15 Rue de l'école de Médecine, 75005, Paris, France.
Abstract
PURPOSE: Although association between colorectal cancer (CRC) and metabolic syndrome (MetS) is established, specific features of CRC arising in patients presenting with MetS have not been clearly identified. METHOD: All patients who underwent colectomy for CRC from January 2005 to December 2014 at Institut Mutualiste Montsouris were identified from a prospectively collected database and characteristics were compared in the entire population and in a 1:2 matched case-control analysis [variables on which matching was performed were CRC localization (right- or left-sided) and AJCC stage (0 to IV)]. RESULTS: Out of the 772 identified patients, 98 (12.7%) presented with MetS. Entire population analysis revealed that CRC associated with MetS was more frequent in men (71.4 vs. 47.8%, p < 0.001), more often right-sided (71.4 vs. 50.4%, p < 0.001) and presented with less synchronous liver metastasis (4.1 vs. 8.7%, p = 0.002). Case-control analysis confirmed the gender association (p < 0.001) and showed HNPCC (p < 0.001) and history family of CRC (p = 0.010) to be significantly more frequent in Non-MetS patients. CONCLUSIONS: CRC associated with MetS is more frequent in men, more often right-sided, and presents with fewer synchronous metastasis. Further investigations should be designed in order to confirm these results and to enhance our knowledge of carcinogenesis related to MetS.
PURPOSE: Although association between colorectal cancer (CRC) and metabolic syndrome (MetS) is established, specific features of CRC arising in patients presenting with MetS have not been clearly identified. METHOD: All patients who underwent colectomy for CRC from January 2005 to December 2014 at Institut Mutualiste Montsouris were identified from a prospectively collected database and characteristics were compared in the entire population and in a 1:2 matched case-control analysis [variables on which matching was performed were CRC localization (right- or left-sided) and AJCC stage (0 to IV)]. RESULTS: Out of the 772 identified patients, 98 (12.7%) presented with MetS. Entire population analysis revealed that CRC associated with MetS was more frequent in men (71.4 vs. 47.8%, p < 0.001), more often right-sided (71.4 vs. 50.4%, p < 0.001) and presented with less synchronous liver metastasis (4.1 vs. 8.7%, p = 0.002). Case-control analysis confirmed the gender association (p < 0.001) and showed HNPCC (p < 0.001) and history family of CRC (p = 0.010) to be significantly more frequent in Non-MetS patients. CONCLUSIONS: CRC associated with MetS is more frequent in men, more often right-sided, and presents with fewer synchronous metastasis. Further investigations should be designed in order to confirm these results and to enhance our knowledge of carcinogenesis related to MetS.