OBJECTIVE: To examine the relationship between estimated maximal cardiorespiratory fitness (CRF) and metabolic syndrome (MetSyn). PATIENTS AND METHODS: We performed a cross-sectional analysis of 38,659 Aerobics Center Longitudinal Study participants seen between January 1, 1979, and December 31, 2006, to examine CRF levels defined as low (lower 20%), moderate (middle 40%), and high (upper 40%) of age- and sex-specific distributions vs National Cholesterol Education Program-derived MetSyn expressed as a summed z-score continuous variable. We used a general linear model for continuous variables, the χ(2) test for distribution of categorical variables, and multiple linear regression for single and cumulative MetSyn scores adjusted for body mass index, smoking status, alcohol intake, and family history of cardiovascular disease. RESULTS: We observed significant inverse trends for MetSyn vs CRF in both sexes (P for trend <.001). The CRF associations vs individual components were as follows: waist circumference-men: β=-.14, r(2)=0.78; women: β=-.04, r(2)=0.71; triglycerides-men: β=-.29, r(2)=0.18; women: β=-.17, r(2)=0.18; high-density lipoprotein cholesterol-men: β=.25, r(2)=0.17; women: β=.08, r(2)=0.19; fasting glucose-men: β=-.09, r(2)=0.09; women: β=.09, r(2)=0.01; systolic blood pressure-men: β=-.09, r(2)=0.09; women: β=-.01, r(2)=0.21; and diastolic blood pressure-men: β=-.07, r(2)=0.12; women: β=-.05, r(2)=0.14. All associations except for systolic blood pressure (both sexes) and glucose (women) are significant (P<.001). CONCLUSION: Cardiorespiratory fitness demonstrated a strong inverse relationship with MetSyn in both sexes, with the strongest single associative component being waist circumference.
OBJECTIVE: To examine the relationship between estimated maximal cardiorespiratory fitness (CRF) and metabolic syndrome (MetSyn). PATIENTS AND METHODS: We performed a cross-sectional analysis of 38,659 Aerobics Center Longitudinal Study participants seen between January 1, 1979, and December 31, 2006, to examine CRF levels defined as low (lower 20%), moderate (middle 40%), and high (upper 40%) of age- and sex-specific distributions vs National Cholesterol Education Program-derived MetSyn expressed as a summed z-score continuous variable. We used a general linear model for continuous variables, the χ(2) test for distribution of categorical variables, and multiple linear regression for single and cumulative MetSyn scores adjusted for body mass index, smoking status, alcohol intake, and family history of cardiovascular disease. RESULTS: We observed significant inverse trends for MetSyn vs CRF in both sexes (P for trend <.001). The CRF associations vs individual components were as follows: waist circumference-men: β=-.14, r(2)=0.78; women: β=-.04, r(2)=0.71; triglycerides-men: β=-.29, r(2)=0.18; women: β=-.17, r(2)=0.18; high-density lipoprotein cholesterol-men: β=.25, r(2)=0.17; women: β=.08, r(2)=0.19; fasting glucose-men: β=-.09, r(2)=0.09; women: β=.09, r(2)=0.01; systolic blood pressure-men: β=-.09, r(2)=0.09; women: β=-.01, r(2)=0.21; and diastolic blood pressure-men: β=-.07, r(2)=0.12; women: β=-.05, r(2)=0.14. All associations except for systolic blood pressure (both sexes) and glucose (women) are significant (P<.001). CONCLUSION:Cardiorespiratory fitness demonstrated a strong inverse relationship with MetSyn in both sexes, with the strongest single associative component being waist circumference.
Authors: Yong-Woo Park; Shankuan Zhu; Latha Palaniappan; Stanley Heshka; Mercedes R Carnethon; Steven B Heymsfield Journal: Arch Intern Med Date: 2003-02-24
Authors: Lana L Watkins; Andrew Sherwood; Mark Feinglos; Alan Hinderliter; Michael Babyak; Elizabeth Gullette; Robert Waugh; James A Blumenthal Journal: Arch Intern Med Date: 2003-09-08
Authors: C P Earnest; M Lupo; J Thibodaux; C Hollier; B Butitta; E Lejeune; N M Johannsen; M J Gibala; T S Church Journal: Int J Sports Med Date: 2012-11-23 Impact factor: 3.118
Authors: David E Laaksonen; Hanna-Maaria Lakka; Jukka T Salonen; Leo K Niskanen; Rainer Rauramaa; Timo A Lakka Journal: Diabetes Care Date: 2002-09 Impact factor: 19.112
Authors: Peter T Katzmarzyk; Arthur S Leon; Jack H Wilmore; James S Skinner; D C Rao; Tuomo Rankinen; Claude Bouchard Journal: Med Sci Sports Exerc Date: 2003-10 Impact factor: 5.411
Authors: Timo A Lakka; David E Laaksonen; Hanna-Maaria Lakka; Niko Männikkö; Leo K Niskanen; Rainer Rauramaa; Jukka T Salonen Journal: Med Sci Sports Exerc Date: 2003-08 Impact factor: 5.411
Authors: Martin Sénéchal; Jonathan M McGavock; Timothy S Church; Duck-Chul Lee; Conrad P Earnest; Xuemei Sui; Steven N Blair Journal: Med Sci Sports Exerc Date: 2014-08 Impact factor: 5.411
Authors: Conrad P Earnest; Neil M Johannsen; Damon L Swift; Fiona B Gillison; Catherine R Mikus; Alejandro Lucia; Kimberly Kramer; Carl J Lavie; Timothy S Church Journal: Med Sci Sports Exerc Date: 2014-07 Impact factor: 5.411
Authors: George S Metsios; R H Moe; M van der Esch; J J C S Veldhuijzen van Zanten; S A M Fenton; Y Koutedakis; P Vitalis; N Kennedy; N Brodin; C Bostrom; T W Swinnen; K Tzika; K Niedermann; E Nikiphorou; G E Fragoulis; T P V M Vlieland; C H M Van den Ende; George D Kitas Journal: Rheumatol Int Date: 2019-12-04 Impact factor: 2.631
Authors: Daniel A Galvão; Dennis R Taaffe; Nigel Spry; Robert A Gardiner; Renea Taylor; Gail P Risbridger; Mark Frydenberg; Michelle Hill; Suzanne K Chambers; Phillip Stricker; Tom Shannon; Dickon Hayne; Eva Zopf; Robert U Newton Journal: Nat Rev Urol Date: 2016-03-08 Impact factor: 14.432
Authors: Jong Im Kim; Sun Ae Kim; Keumok Park; Jiyoung Kim; Lina Lee; Si Wan Choi; Bon Jeong Ku Journal: J Korean Acad Nurs Date: 2020-08 Impact factor: 0.984
Authors: Conrad P Earnest; Neil M Johannsen; Damon L Swift; Carl J Lavie; Steven N Blair; Timothy S Church Journal: Am J Cardiol Date: 2013-04-08 Impact factor: 2.778