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Literature DB >> 2339055

One pot solution synthesis of cyclic oligodeoxyribonucleotides.

M L Capobianco¹, A Carcuro, L Tondelli, A Garbesi, G M Bonora.
1. ICoCEA-CNR, Bologna, Italy.

Abstract

Several cyclic oligodeoxynucleotides with different base composition and size have been prepared from 5',3'-unprotected linear precursors, using a bifunctional phosphorylating reagent. The final deprotected oligomers have been characterized by 1H- and 31P-NMR. The present procedure is particularly useful for millimolar scale syntheses.

Entities: Chemical

Mesh：

Substances：

Year: 1990 PMID： 2339055 PMCID： PMC330750 DOI： 10.1093/nar/18.9.2661

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

6 in total

1. Synthesis of cyclic oligodeoxyribonucleotides via the 'filtration' approach.

Authors: M V Rao; C B Reese
Journal: Nucleic Acids Res Date: 1989-10-25 Impact factor: 16.971

2. Use of a 1-hydroxybenzotriazole activated phosphorylating reagent towards the synthesis of short RNA fragments in solution.

Authors: E de Vroom; A Fidder; J E Marugg; G A van der Marel; J H van Boom
Journal: Nucleic Acids Res Date: 1986-07-25 Impact factor: 16.971

3. Studies on transfer ribonucleic acids and related compounds. XXVI. Circular dichroic properties of cyclic oligoribonucleotides and their linear counterparts.

Authors: A F Markham; E Nakagawa; E Ohtsuka; M Ikehara
Journal: Biopolymers Date: 1980-02 Impact factor: 2.505

4. RNA polymerase: linear competitive inhibition by bis-(3' to 5')-cyclic dinucleotides,NpNp.

Authors: C Y Hsu; D Dennis
Journal: Nucleic Acids Res Date: 1982-09-25 Impact factor: 16.971

5. Solution structure of the 3'-5' cyclic dinucleotide d(pApA). A combined NMR, UV melting, and molecular mechanics study.

Authors: M J Blommers; C A Haasnoot; J A Walters; G A van der Marel; J H van Boom; C W Hilbers
Journal: Biochemistry Date: 1988-11-01 Impact factor: 3.162

6. Synthesis of cyclic oligonucleotides by a modified phosphotriester approach.

Authors: E de Vroom; H J Broxterman; L A Sliedregt; G A van der Marel; J H van Boom
Journal: Nucleic Acids Res Date: 1988-05-25 Impact factor: 16.971

6 in total

7 in total

One pot solution synthesis of cyclic oligodeoxyribonucleotides.

1. Synthesis of cyclic oligodeoxyribonucleotides via the 'filtration' approach.

2. Use of a 1-hydroxybenzotriazole activated phosphorylating reagent towards the synthesis of short RNA fragments in solution.

3. Studies on transfer ribonucleic acids and related compounds. XXVI. Circular dichroic properties of cyclic oligoribonucleotides and their linear counterparts.

4. RNA polymerase: linear competitive inhibition by bis-(3' to 5')-cyclic dinucleotides,NpNp.

5. Solution structure of the 3'-5' cyclic dinucleotide d(pApA). A combined NMR, UV melting, and molecular mechanics study.

6. Synthesis of cyclic oligonucleotides by a modified phosphotriester approach.

1. Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides.

2. Recognition of DNA, RNA, and Proteins by Circular Oligonucleotides.

3. Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with circular DNAs.

4. Molecular Recognition by Circular Oligonucleotides. Strong Binding of Single-stranded DNA and RNA.

5. Topologically Modified Biopolymers: Properties of Synthetic Circular DNAs and RNAs.

6. Circulation of oligonucleotides by disulfide bridge formation.

7. Convergent DNA synthesis: a non-enzymatic dimerization approach to circular oligodeoxynucleotides.