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Literature DB >> 23390246

Targeting protein prenylation in progeria.

Stephen G Young¹, Shao H Yang, Brandon S J Davies, Hea-Jin Jung, Loren G Fong.

Abstract

A clinical trial of a protein farnesyltransferase inhibitor (lonafarnib) for the treatment of Hutchinson-Gilford progeria syndrome (HGPS) was recently completed. Here, we discuss the mutation that causes HGPS, the rationale for inhibiting protein farnesyltransferase, the potential limitations of this therapeutic approach, and new potential strategies for treating the disease.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23390246 PMCID： PMC3725554 DOI： 10.1126/scitranslmed.3005229

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

39 in total

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Journal: Nat Genet Date: 2002-04-01 Impact factor: 38.330

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Journal: Nature Date: 2003-04-25 Impact factor: 49.962

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Journal: Annu Rev Biochem Date: 1996 Impact factor: 23.643

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24 in total

Review 1. Rho-kinase: regulation, (dys)function, and inhibition.

Authors: Ehsan Amin; Badri Nath Dubey; Si-Cai Zhang; Lothar Gremer; Radovan Dvorsky; Jens M Moll; Mohamed S Taha; Luitgard Nagel-Steger; Roland P Piekorz; Avril V Somlyo; Mohammad R Ahmadian
Journal: Biol Chem Date: 2013-11 Impact factor: 3.915

2. An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin.

Authors: Hea-Jin Jung; Angelica Tatar; Yiping Tu; Chika Nobumori; Shao H Yang; Chris N Goulbourne; Harald Herrmann; Loren G Fong; Stephen G Young
Journal: Mol Cell Biol Date: 2014-10-13 Impact factor: 4.272

Review 3. Nuclear lamins and neurobiology.

Authors: Stephen G Young; Hea-Jin Jung; John M Lee; Loren G Fong
Journal: Mol Cell Biol Date: 2014-05-19 Impact factor: 4.272

4. Selective Gas-Phase Oxidation and Localization of Alkylated Cysteine Residues in Polypeptide Ions via Ion/Ion Chemistry.

Authors: Alice L Pilo; Feifei Zhao; Scott A McLuckey
Journal: J Proteome Res Date: 2016-08-18 Impact factor: 4.466

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Authors: Eric W Lin; Graham F Brady; Raymond Kwan; Alexey I Nesvizhskii; M Bishr Omary
Journal: FASEB J Date: 2020-05-15 Impact factor: 5.191