| Literature DB >> 23950574 |
Ehsan Amin, Badri Nath Dubey, Si-Cai Zhang, Lothar Gremer, Radovan Dvorsky, Jens M Moll, Mohamed S Taha, Luitgard Nagel-Steger, Roland P Piekorz, Avril V Somlyo, Mohammad R Ahmadian.
Abstract
In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and adhesion plaques as well as in the regulation of transcription factors. Thus, ROCKI/II activity regulates cellular contraction, motility, morphology, polarity, cell division, and gene expression. Emerging evidence suggests that dysregulation of the Rho-ROCK pathways at different stages is linked to cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. This review focuses on the current status of understanding the multiple functions of Rho-ROCK signaling pathways and various modes of regulation of Rho-ROCK activity, thereby orchestrating a concerted functional response.Entities:
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Year: 2013 PMID： 23950574 PMCID： PMC5538733 DOI： 10.1515/hsz-2013-0181
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915