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Literature DB >> 23390001

H5N1 avian flu research and the ethics of knowledge.

Abstract

How can we best address the threat posed by dual-use research? By concentrating on the benefits of the knowledge and publishing it anyway? By keeping some of the research secret from the general public, making it available in full only to responsible scientists? Or by not publishing it -- or, in some cases, not even conducting it at all?

Entities: Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23390001 PMCID： PMC3953619 DOI： 10.1002/hast.143

Source DB: PubMed Journal: Hastings Cent Rep ISSN： 0093-0334 Impact factor: 2.683

26 in total

1. Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.

Authors: Jeronimo Cello; Aniko V Paul; Eckard Wimmer
Journal: Science Date: 2002-07-11 Impact factor: 47.728

2. The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host.

Authors: Colin A Russell; Judith M Fonville; André E X Brown; David F Burke; David L Smith; Sarah L James; Sander Herfst; Sander van Boheemen; Martin Linster; Eefje J Schrauwen; Leah Katzelnick; Ana Mosterín; Thijs Kuiken; Eileen Maher; Gabriele Neumann; Albert D M E Osterhaus; Yoshihiro Kawaoka; Ron A M Fouchier; Derek J Smith
Journal: Science Date: 2012-06-22 Impact factor: 47.728

3. Analyzing a bioterror attack on the food supply: the case of botulinum toxin in milk.

Authors: Lawrence M Wein; Yifan Liu
Journal: Proc Natl Acad Sci U S A Date: 2005-06-28 Impact factor: 11.205

4. The dual-use dilemma for the life sciences: perspectives, conundrums, and global solutions.

Authors: Ronald M Atlas; Malcolm Dando
Journal: Biosecur Bioterror Date: 2006

5. A tale of two studies; ethics, bioterrorism, and the censorship of science.

Authors: Michael J Selgelid
Journal: Hastings Cent Rep Date: 2007 May-Jun Impact factor: 2.683

6. Science, democracy, and the right to research.

Authors: Mark B Brown; David H Guston
Journal: Sci Eng Ethics Date: 2009-05-12 Impact factor: 3.525

7. Scientific leaders balk at broad data release.

Authors: B Agnew
Journal: Science Date: 1999-01-15 Impact factor: 47.728

8. Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

Authors: R J Jackson; A J Ramsay; C D Christensen; S Beaton; D F Hall; I A Ramshaw
Journal: J Virol Date: 2001-02 Impact factor: 5.103

9. Characterization of the reconstructed 1918 Spanish influenza pandemic virus.

Authors: Terrence M Tumpey; Christopher F Basler; Patricia V Aguilar; Hui Zeng; Alicia Solórzano; David E Swayne; Nancy J Cox; Jacqueline M Katz; Jeffery K Taubenberger; Peter Palese; Adolfo García-Sastre
Journal: Science Date: 2005-10-07 Impact factor: 47.728

H5N1 avian flu research and the ethics of knowledge.

1. Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.

2. The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host.

3. Analyzing a bioterror attack on the food supply: the case of botulinum toxin in milk.

4. The dual-use dilemma for the life sciences: perspectives, conundrums, and global solutions.

5. A tale of two studies; ethics, bioterrorism, and the censorship of science.

6. Science, democracy, and the right to research.

7. Scientific leaders balk at broad data release.

8. Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

9. Characterization of the reconstructed 1918 Spanish influenza pandemic virus.

10. The chilling effect: how do researchers react to controversy?

1. Moral Distress in Scientific Research.

2. The Ethical Challenges of Socially Responsible Science.

3. Dual-use decision making: relational and positional issues.

4. Biosecurity Policy in the US: A Critical Assessment.

5. Gain-of-Function Research: Ethical Analysis.

6. Surviving a technological future: Technological proliferation and modes of discovery.