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Literature DB >> 233898

Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro.

Abstract

A sensitive procedure employing limiting dilution of activated lymphocytes and 51Cr release from highly labeled target cells was used to derive minimal estimates of the absolute frequency of cytotoxic T lymphocytes (CTL) present in a population of mouse lymphocytes activated to alloantigens of the major histocompatibility complex in bulk mixed lymphocyte cultures. From this figure (0.7-1.2%), the maximal rate of target cell killing could be calculated to be approximately 4 targets/CTL/hour.

Entities: Disease Species

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Year: 1977 PMID： 233898 PMCID： PMC2180717 DOI： 10.1084/jem.145.3.500

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

9 in total

1. Direct estimation of frequency of cytotoxic T lymphocytes by a modified plaque assay.

Authors: B Bonavida; B Ikejiri; E Kedar
Journal: Nature Date: 1976-10-28 Impact factor: 49.962

2. Precursor cells specific to sheep red cells in nude mice. Estimation of frequency in the microculture system.

Authors: J Quintáns; I Lefkovits
Journal: Eur J Immunol Date: 1973-07 Impact factor: 5.532

3. Further evidence for autonomy of T cells mediating specific in vitro cytotoxicity: efficiency of very small amounts of highly purified T cells.

Authors: P Golstein; H Blomgren
Journal: Cell Immunol Date: 1973-10 Impact factor: 4.868

4. Cell-mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse.

Authors: M Nabholz; J Vives; H M Young; T Meo; V Miggiano; A Rijnbeek; D C Shreffler
Journal: Eur J Immunol Date: 1974-05 Impact factor: 5.532

Review 5. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.

Authors: J C Cerottini; K T Brunner
Journal: Adv Immunol Date: 1974 Impact factor: 3.543

6. Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization.

Authors: E Martz
Journal: J Immunol Date: 1975-07 Impact factor: 5.422

7. Quantitation of the cell-mediated immune response. I. The number of cytolytically active mouse lymphoid cells induced by immunization with allogeneic mastocytoma cells.

Authors: C S Henney
Journal: J Immunol Date: 1971-12 Impact factor: 5.422

8. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

Authors: K F Lindahl; D B Wilson
Journal: J Exp Med Date: 1977-03-01 Impact factor: 14.307

9. QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : I. RELATIONSHIP OF THE DEGREE OF DESTRUCTION OF HOMOLOGOUS TARGET CELLS TO THE NUMBER OF LYMPHOCYTES AND TO THE TIME OF CONTACT IN CULTURE AND CONSIDERATION OF THE EFFECTS OF ISOIMMUNE SERUM.

Authors: D B Wilson
Journal: J Exp Med Date: 1965-07-01 Impact factor: 14.307

9 in total

19 in total

9. Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay.

Authors: Ozlem Tapirdamaz; Shanta Mancham; Luc J W van der Laan; Geert Kazemier; Kris Thielemans; Herold J Metselaar; Jaap Kwekkeboom
Journal: PLoS One Date: 2010-12-29 Impact factor: 3.240

10. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

Authors: K F Lindahl; D B Wilson
Journal: J Exp Med Date: 1977-03-01 Impact factor: 14.307

Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro.

1. Direct estimation of frequency of cytotoxic T lymphocytes by a modified plaque assay.

2. Precursor cells specific to sheep red cells in nude mice. Estimation of frequency in the microculture system.

3. Further evidence for autonomy of T cells mediating specific in vitro cytotoxicity: efficiency of very small amounts of highly purified T cells.

4. Cell-mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse.

Review 5. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.

6. Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization.

7. Quantitation of the cell-mediated immune response. I. The number of cytolytically active mouse lymphoid cells induced by immunization with allogeneic mastocytoma cells.

8. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

9. QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : I. RELATIONSHIP OF THE DEGREE OF DESTRUCTION OF HOMOLOGOUS TARGET CELLS TO THE NUMBER OF LYMPHOCYTES AND TO THE TIME OF CONTACT IN CULTURE AND CONSIDERATION OF THE EFFECTS OF ISOIMMUNE SERUM.

Review 1. Immunological considerations for embryonic and induced pluripotent stem cell banking.

2. Natural killer cells in viral arthritis.

Review 3. T cell clones: their use for the study of specificity, induction, and effector-function of T cells.

Review 4. T regulatory cells and transplantation tolerance.

Review 5. Tempering allorecognition to induce transplant tolerance with chemically modified apoptotic donor cells.

6. Differential roles of direct and indirect allorecognition pathways in the rejection of skin and corneal transplants.

7. Restricted and conserved T-cell repertoires involved in allorecognition of class II major histocompatibility complex.

8. Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens.

9. Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay.

10. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.