Literature DB >> 233821

Evidence for a role of alpha-adrenergic mechanisms in regulation of episodic growth hormone secretion in the rat.

D Durand1, J B Martin, P Brazeau.   

Abstract

The role of catecholamines in regulation of episodic GH secretion was investigated in the male rat. Administration of alpha-methyl-p-tyrosine (alpha-MT; 250 mg/kg ip) caused significant suppression of GH bursts and resulted in marked elevation of plasma PRL. Intravenous administration of apomorphine (.03 and .1 mg/kg) had no effect on decreased GH levels, whereas clonidine (150 micrograms/kg) restored GH secretion. Apomorphine significantly reduced PRL levels in alpha-MT-treated rats whereas, clonidine resulted in a further increase in PRL.

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Year:  1977        PMID： 233821     DOI： 10.1210/endo-100-3-722

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  10 in total

Review 1.  Clonidine treatment in children with short stature.

Authors:  S Loche; A Lampis; S G Cella; V Locatelli; E E Müller; C Pintor
Journal:  J Endocrinol Invest       Date:  1988-11       Impact factor: 4.256

2.  Hypothalamic control of GH secretion: pathophysiology and clinical implications.

Authors:  H J Quabbe
Journal:  Acta Neurochir (Wien)       Date:  1985       Impact factor: 2.216

3.  Serotonergic influence on the growth hormone response to clonidine in rat.

Authors:  B Söderpalm; L Andersson; M Carlsson; K Modigh; E Eriksson
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

Review 4.  Involvement of brain catecholamines and acetylcholine in growth hormone deficiency states. Pathophysiological, diagnostic and therapeutic implications.

Authors:  E E Müller; V Locatelli; E Ghigo; S G Cella; S Loche; C Pintor; F Camanni
Journal:  Drugs       Date:  1991-02       Impact factor: 9.546

5.  Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat.

Authors:  M Grealy; J M O'Donnell
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

6.  Up- and down- regulation of central postsynaptic alpha 2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats.

Authors:  E Eriksson; S Edén; K Modigh
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

7.  Neuroendocrine response to clonidine and 8-OH-DPAT in rats following chronic administration of desipramine or sertraline.

Authors:  J M O'Donnell; M Grealy
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

8.  Regulation of episodic growth hormone secretion by the central epinephrine system. Studies in the chronically cannulated rat.

Authors:  L C Terry; W R Crowley; M D Johnson
Journal:  J Clin Invest       Date:  1982-01       Impact factor: 14.808

9.  Ultradian rhythm in rat hypothalamic dopamine levels.

Authors:  E Eriksson; K Modigh; J Häggendal
Journal:  J Neural Transm       Date:  1980       Impact factor: 3.575

10.  Effects of sex steroids on growth hormone responses to clonidine and GHRH in reserpine pretreated rats.

Authors:  E Eriksson; K Modigh; J O Jansson
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575
  10 in total

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