Literature DB >> 2338120

Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man.

C A Maggi1, P Lualdi, G Mautone.   

Abstract

A phamacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets. Oral DIEP 2 X 50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to oral diclofenac sodium 2 X 50 mg. A relevant plasma concentration of diclofenac was detected just 15 min after DIEP, while diclofenac sodium produced a measurable plasma concentration only 0.5-1 h after the treatment. Cmax and t1/2 after DIEP and diclofenac sodium were comparable. Comparison of the two AUC values showed that DIEP was bioequivalent to diclofenac sodium (Q = 100%).

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Year:  1990        PMID： 2338120     DOI： 10.1007/bf00265987

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  5 in total

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Authors:  C Gomeni; R Gomeni
Journal:  Comput Biomed Res       Date:  1978-08

2.  Pharmacokinetics and metabolism of the anti-inflammatory agent Voltaren.

Authors:  W Riess; H Stierlin; P Degen; J W Faigle; A Gérardin; J Moppert; A Sallmann; K Schmid; A Schweizer; M Sulc; W Theobald; J Wagner
Journal:  Scand J Rheumatol Suppl       Date:  1978

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Authors:  U P Geiger; P H Degen; A Sioufi
Journal:  J Chromatogr       Date:  1975-09-03

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Authors:  J V Willis; M J Kendall; R M Flinn; D P Thornhill; P G Welling
Journal:  Eur J Clin Pharmacol       Date:  1979       Impact factor: 2.953

Review 5.  Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.

Authors:  R N Brogden; R C Heel; G E Pakes; T M Speight; G S Avery
Journal:  Drugs       Date:  1980-07       Impact factor: 9.546
  5 in total
  3 in total

Review 1.  Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls.

Authors:  N M Davies; K E Anderson
Journal:  Clin Pharmacokinet       Date:  1997-09       Impact factor: 6.447

2.  Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers.

Authors:  P Stadler; D Armstrong; D Margalith; E Saraga; M Stolte; P Lualdi; G Mautone; A L Blum
Journal:  Dig Dis Sci       Date:  1991-05       Impact factor: 3.199

3.  Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.

Authors:  David R Lionberger; Michael J Brennan
Journal:  J Pain Res       Date:  2010-11-10       Impact factor: 3.133
  3 in total

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