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Literature DB >> 23380726

Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii.

Saito Higuchi¹, Yoshikuni Onodera, Megumi Chiba, Kazuki Hoshino, Naomasa Gotoh.

Abstract

We investigated the in vitro activity of DS-8587, a novel fluoroquinolone, against Acinetobacter baumannii. The MICs of DS-8587 against clinical isolates and its inhibitory activity against target enzymes were superior to those of ciprofloxacin and levofloxacin. Furthermore, the antibacterial activity of DS-8587 was less affected by adeA/adeB/adeC or abeM efflux pumps than was that of ciprofloxacin and the frequency of single-step mutations with DS-8587 was lower than that with ciprofloxacin. DS-8587 might be an effective agent against A. baumannii infection.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2013 PMID： 23380726 PMCID： PMC3623304 DOI： 10.1128/AAC.02374-12

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

1. Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region.

Authors: Hsien Chang Chang; Yu Fang Wei; Lenie Dijkshoorn; Mario Vaneechoutte; Chung Tao Tang; Tsung Chain Chang
Journal: J Clin Microbiol Date: 2005-04 Impact factor: 5.948

Review 2. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features.

Authors: E Bergogne-Bérézin; K J Towner
Journal: Clin Microbiol Rev Date: 1996-04 Impact factor: 26.132

3. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species.

Authors: Jane F Turton; Neil Woodford; Judith Glover; Susannah Yarde; Mary E Kaufmann; Tyrone L Pitt
Journal: J Clin Microbiol Date: 2006-08 Impact factor: 5.948

Review 4. Acinetobacter baumannii: an emerging multidrug-resistant threat.

Authors: Thomas D Gootz; Andrea Marra
Journal: Expert Rev Anti Infect Ther Date: 2008-06 Impact factor: 5.091

Review 5. Acinetobacter baumannii: emergence of a successful pathogen.

Authors: Anton Y Peleg; Harald Seifert; David L Paterson
Journal: Clin Microbiol Rev Date: 2008-07 Impact factor: 26.132

Review 6. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii.

Authors: Lenie Dijkshoorn; Alexandr Nemec; Harald Seifert
Journal: Nat Rev Microbiol Date: 2007-12 Impact factor: 60.633

7. Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.

Authors: Simona Bratu; David Landman; Don Antonio Martin; Claudiu Georgescu; John Quale
Journal: Antimicrob Agents Chemother Date: 2008-06-30 Impact factor: 5.191

8. CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii.

Authors: I Roca; S Marti; P Espinal; P Martínez; I Gibert; J Vila
Journal: Antimicrob Agents Chemother Date: 2009-07-06 Impact factor: 5.191

9. Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae.

Authors: Ryo Okumura; Tsuyoshi Hirata; Yoshikuni Onodera; Kazuki Hoshino; Tsuyoshi Otani; Tomoko Yamamoto
Journal: J Antimicrob Chemother Date: 2008-04-04 Impact factor: 5.790

Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii.

1. Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region.

Review 2. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features.

3. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species.

Review 4. Acinetobacter baumannii: an emerging multidrug-resistant threat.

Review 5. Acinetobacter baumannii: emergence of a successful pathogen.

Review 6. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii.

7. Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.

8. CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii.

9. Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae.

10. Triclosan resistance in clinical isolates of Acinetobacter baumannii.

Review 1. Investigational antimicrobial agents of 2013.

Review 2. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Review 3. Insights into Newer Antimicrobial Agents Against Gram-negative Bacteria.

Review 4. Transferable Mechanisms of Quinolone Resistance from 1998 Onward.

Review 5. Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020.

6. Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.

Review 7. Pipeline of Known Chemical Classes of Antibiotics.